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Pharmacology Reference

Iboga Alkaloid Encyclopedia

Clinician-grade reference for the 12+ indole alkaloids in Tabernanthe iboga root bark and full-spectrum total alkaloid (TA) extract. Each entry includes formula, approximate TA share, receptor profile, and the role the alkaloid plays in MindScape's onsite taper bridge versus the ibogaine HCl flood dose.

DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 1,000 patients treated.
Last reviewed: May 2026 · See full medical team

Quick Answer

What alkaloids are in iboga total alkaloid (TA)?

Iboga total alkaloid (TA) extracted from Tabernanthe iboga root bark contains 12+ indole alkaloids. Ibogaine is the dominant psychoactive constituent (~80% of mass). Noribogaine is the long-half-life active metabolite formed in vivo. Minor alkaloids including ibogamine, voacangine, tabernanthine, coronaridine, ibogaline, conopharyngine, iboluteine, iboquine, ibogamiline, and voacristine each contribute distinct receptor coverage to full-spectrum TA — which is why a sub-psychoactive TA bridge behaves differently from sub-psychoactive ibogaine HCl alone.

Reviewed by Dr. Arellano, M.D. — May 2026

TA vs HCl

Total alkaloid (TA) is not the same as ibogaine HCl

Iboga TA is the full-spectrum extract — every alkaloid below in their natural ratios — used at sub-psychoactive doses (typically 50–150 mg BID) during MindScape's onsite taper to bridge SSRI/SNRI/benzodiazepine and short-acting opioid discontinuation under continuous cardiac telemetry. Ibogaine HCl is the isolated hydrochloride salt of ibogaine alone, reserved for the flood dose after every safety threshold has been cleared. Read the full TA vs HCl comparison →

Primary Psychoactive

The dominant indole alkaloid by mass in Tabernanthe iboga root bark and the molecule used at flood-dose.

Active Metabolite

In vivo metabolites that carry the long-tail clinical effect after the parent alkaloid clears.

Minor Alkaloids

Lower-share constituents of full-spectrum TA whose receptor coverage broadens the bridging effect during taper.

Ibogamine

C₁₉H₂₄N₂ · 280.41 g/mol

Cardiac-sparing minor indole alkaloid in iboga TA — present at meaningful share, contributes to TA's broader receptor footprint.

Tabernanthine

C₂₀H₂₆N₂O · 310.43 g/mol

Mild psychoactive minor indole alkaloid in iboga TA; isomeric cousin of ibogaine.

Coronaridine

C₂₁H₂₆N₂O₂ · 338.45 g/mol

Anti-inflammatory minor iboga-type alkaloid; nicotinic acetylcholine receptor activity.

Ibogaline

C₂₁H₂₈N₂O₂ · 340.46 g/mol

Methoxylated ibogaine analog present at trace levels in iboga root bark.

Conopharyngine

C₂₃H₃₀N₂O₃ · 382.50 g/mol

Minor iboga-type indole alkaloid; member of the broader iboga alkaloid family.

Iboluteine

C₂₀H₂₄N₂O₂ · 324.42 g/mol

Iboga-type indole alkaloid; minor TA constituent.

Iboquine

C₁₉H₂₂N₂O · 294.39 g/mol

Trace iboga indole alkaloid; included in full-spectrum TA characterization.

Ibogamiline

C₂₀H₂₆N₂O · 310.43 g/mol

Methoxylated ibogamine-related alkaloid; minor TA constituent.

Voacristine

C₂₂H₂₈N₂O₄ · 384.47 g/mol

Hydroxy-voacangine relative; minor iboga-family indole alkaloid.

Precursor Alkaloids

Biosynthetic precursors and structural relatives present at trace-to-low levels in TA.

Related references

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