Iboga Alkaloid Encyclopedia · Minor Alkaloid
Tabernanthine
Mild psychoactive minor indole alkaloid in iboga TA; isomeric cousin of ibogaine.
Molecular formula
C₂₀H₂₆N₂O
Molecular weight
310.43 g/mol
CAS registry
1990-51-4
TA share (approx.)
≈ 1–5% of TA mass
IUPAC / systematic
Tabernanthine (13-methoxyibogamine)
Profile
Tabernanthine is a positional isomer of ibogaine — the methoxy group is at a different position on the indole core. It contributes mild psychoactivity at higher doses and is one of the alkaloids responsible for the experiential profile differences between iboga TA and pure ibogaine HCl reported in clinical observation literature.
Receptor & Target Profile
- Mu-opioid receptor: low-affinity activity reported.
- NMDA receptor: low-affinity antagonism reported.
Role at MindScape
Minor share of TA; contributes to the multi-receptor footprint of the bridge.
Citations
- Alper KR. (2001). The Alkaloids: Chemistry and Biology, 56, 1-38.
Citation list is illustrative. Where peer-reviewed data is thin or absent, MindScape's pharmacology summary draws on textbook references (Alper 2001 — The Alkaloids: Chemistry and Biology, vol. 56) and is hedged accordingly.