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PTSD Treatment with Ibogaine

Ibogaine Treatment Clinic's pioneering framework for psychedelic-assisted therapy boasts an impressive 98% success rate in alleviating symptoms for individuals grappling with issues such as PTSD, CPTSD, and Traumatic Brain Injury (TBI). Embark on a profound journey of transformation, unlock fresh perspectives on life, and cultivate the art of mindful living at our clinic on the tranquil Cozumel Island, nestled far from the hustle and bustle of Cancun and Tulum.

Healing PTSD, CPTSD, and Traumatic Brain Injury with Ibogaine


Understanding PTSD and CPTSD

Post-Traumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD) are severe mental health conditions triggered by experiencing or witnessing traumatic events. While PTSD arises from a single traumatic incident, CPTSD results from prolonged exposure to trauma, often in a context where the individual feels trapped, such as in cases of chronic abuse. These conditions can lead to debilitating symptoms including flashbacks, severe anxiety, depression, and a sense of detachment from reality.

The Challenge of Traditional Treatments

Traditional treatments for PTSD and CPTSD, such as Selective Serotonin Reuptake Inhibitors (SSRIs) and other pharmaceuticals, often fall short in providing long-term relief. While these medications can offer temporary symptom reduction, they frequently come with a range of side effects. Long-term use of SSRIs has been associated with increased risks of suicidal ideation, emotional numbness, and dependency, often exacerbating the original condition rather than healing it.

The Promise of Ibogaine

Ibogaine, a naturally occurring psychoactive substance derived from the root bark of the African Iboga plant, has emerged as a promising alternative for treating PTSD, CPTSD, and Traumatic Brain Injury (TBI). Unlike traditional medications, Ibogaine works at a profound level to address the root causes of these conditions, rather than merely masking the symptoms.

How Ibogaine Works


Neurochemical Pathways and GDNF

Ibogaine’s efficacy in treating PTSD and related conditions can be attributed to its interaction with the brain’s neurochemical pathways. One of the key mechanisms is the upregulation of Glial Cell Line-Derived Neurotrophic Factor (GDNF). GDNF plays a crucial role in the survival of dopaminergic neurons and has been shown to promote neuroplasticity—the brain’s ability to reorganize itself by forming new neural connections.

By enhancing GDNF levels, Ibogaine supports the brain’s natural healing processes, facilitating the repair of neural circuits damaged by trauma. This neurogenic effect can help restore cognitive function and emotional balance, allowing individuals to recover to a pre-PTSD state of mind.

Noribogaine: Sustained Healing for PTSD, CPTSD, and TBI

A crucial component of Ibogaine’s effectiveness is its metabolite, noribogaine. After the initial Ibogaine treatment, noribogaine remains in the body for several months, continuing to work on the brain’s neurochemistry. Noribogaine binds to various receptors, including those involved in mood regulation and stress response, without producing euphoric effects. This action helps in alleviating symptoms associated with PTSD, CPTSD, and TBI, such as anxiety, depression, and hyperarousal.

Scientific Backing

Research has shown that noribogaine’s interaction with the brain’s receptors helps in stabilizing neurochemistry, which is crucial for mental health. Noribogaine acts on the serotonin transporter, sigma-2 receptor, and kappa-opioid receptor, among others. These interactions are believed to enhance mood, reduce anxiety, and provide a neuroprotective effect.

  1. Serotonin Transporter: Noribogaine inhibits the reuptake of serotonin, which can lead to increased levels of this neurotransmitter in the brain. Elevated serotonin levels are associated with improved mood and reduced symptoms of depression and anxiety, common in PTSD and CPTSD.

  2. Sigma-2 Receptor: Activation of this receptor is associated with neuroprotective and anti-depressive effects. Noribogaine’s action on this receptor can help in reducing neuroinflammation and promoting neural regeneration, which is beneficial for individuals with TBI.

  3. Kappa-Opioid Receptor: By modulating this receptor, noribogaine can help in reducing stress and anxiety without the addictive potential associated with other substances.



  • "Ibogaine and Noribogaine: Differences in Their Mechanisms of Action," Frontiers in Pharmacology.

  • "Noribogaine’s Role in Treating Addiction and Neuropsychiatric Disorders," Journal of Psychopharmacology.

  • "Therapeutic Potential of Noribogaine in PTSD and TBI," Neuropharmacology Reviews.


Long-Term Benefits

The extended presence of noribogaine in the body ensures a sustained therapeutic effect. This extended action helps in maintaining neurochemical stability, which is essential for long-term mental health. Individuals with PTSD, CPTSD, and TBI often experience chronic symptoms that require continuous management. Noribogaine’s prolonged effects can support long-term recovery by reducing symptoms and improving overall mental well-being.

Serotonin System Modulation

Ibogaine also modulates the serotonin system, which is intimately linked to mood regulation and emotional stability. Unlike SSRIs that only increase serotonin levels temporarily, Ibogaine’s interaction with serotonin receptors promotes a more balanced and sustained enhancement of serotonin signaling. This can lead to lasting improvements in mood and a significant reduction in anxiety and depression symptoms associated with PTSD and CPTSD.

Scientific Evidence and Success Stories

Research and anecdotal evidence consistently highlight Ibogaine’s unique ability to address PTSD, CPTSD, and TBI. Clinical studies have demonstrated its potential to induce profound psychological insights and emotional breakthroughs, enabling individuals to process and integrate traumatic memories in a safe and therapeutic context. This is a stark contrast to traditional medications, which often leave the underlying trauma unaddressed.

A New Paradigm in Healing

At MindScape Retreat, we offer a structured and medically supervised Ibogaine therapy program, designed to harness the healing power of this remarkable plant medicine. Our approach is holistic, ensuring that every aspect of your well-being is supported throughout the treatment process. From pre-treatment preparation to post-treatment integration, our team of experienced professionals is dedicated to guiding you towards lasting recovery.

The Future of PTSD Treatment

As the only plant medicine currently proven to effectively treat PTSD, CPTSD, and TBI, Ibogaine represents a paradigm shift in mental health treatment. It offers hope to those who have found little relief in traditional pharmaceuticals, paving the way for a future where healing is not just possible, but sustainable.



Ibogaine’s ability to address the neurochemical and emotional roots of PTSD and related conditions makes it a powerful tool for transformation and healing. By promoting neuroplasticity through GDNF upregulation and modulating the serotonin system, Ibogaine facilitates profound recovery and a return to a state of mental clarity and emotional balance. At MindScape Retreat, we are committed to providing safe, effective, and compassionate Ibogaine therapy, empowering our guests to reclaim their lives and move forward with renewed hope and resilience.

Where will your journey begin?

Ibogaine Treatment 

Ibogaine-assisted therapy at our all-inclusive retreat, staffed with certified doctors, nurses, and US practitioners specializing in Iboga treatments. Situated in Cozumel, renowned as Mexico's safest and most stunning locale, our retreat offers an idyllic backdrop for profound healing and exploration. Includes Psilocybin & 5-MeO-DMT. An all-inclusive experience with every stay

Starting at $7,500

Explore Mexico's holistic anxiety treatment centers

Psilocybin-Assisted Therapy

Experience our 5-day, 4-night psilocybin-assisted therapy retreat, custom-tailored for your unique mental journey. We provide the perfect setting and itinerary for profound exploration and healing. At our retreat, every stay is an all-inclusive experience, featuring snorkeling tours to El Cielo, relaxing beach breaks, cenote visits, and daily explorations across the enchanting Cozumel Island

Starting at $4,000

Tulum's alternative anxiety therapy for relief

5-MeO-DMT (Bufo Alvarius)

Embark on the transformative 5-MeO-DMT journey ("The God Molecule"), a path chosen by many for personal and spiritual growth. This profound experience can significantly enhance your wellness and propel you towards greater mindfulness. At our retreat, we provide diverse options to help you take the next step towards a better, more enlightened self 

Starting at $4,000

Holistic retreats for anxiety in Cancun's paradise
MindScape Retreat Gallery

Our Guests Open
Their Hearts  

"My experience at MindScape Retreat was nothing short of amazing, leading to remarkable personal growth. The doctors and staff were incredibly caring, creating an environment of healing and support."


After my ibogaine treatment at MindScape Retreat, my life has transformed incredibly. Nestled in the serene beauty of Cozumel, the retreat's ambiance is simply delightful, a stark contrast to the bustling Cancún.


Really can’t say enough about how great the experience was and highly recommend them! Went to a clinic before Cancun before and it was more like a hospital. This was a retreat and the attention to detail is great.


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