top of page

Methadone & Suboxone Treatment

Ibogaine Treatment Clinic's pioneering framework for psychedelic-assisted therapy boasts an impressive 98% success rate in alleviating symptoms for individuals grappling with issues such as Methadone & Suboxone. Embark on a profound journey of transformation, unlock fresh perspectives on life, and cultivate the art of mindful living at our clinic on the tranquil Cozumel Island, nestled far from the hustle and bustle of Cancun and Tulum.

Transforming Methadone and Suboxone Dependence with Ibogaine Therapy


Understanding Methadone and Suboxone Dependence

Methadone and Suboxone are widely used in the treatment of opioid addiction. Methadone, a long-acting opioid agonist, and Suboxone, a combination of buprenorphine (a partial opioid agonist) and naloxone (an opioid antagonist), are designed to reduce cravings and withdrawal symptoms, helping individuals manage their addiction. However, while these medications can stabilize patients, they often lead to long-term dependency and do not address the root causes of addiction.

The Limitations of Traditional Maintenance Therapies

Both Methadone and Suboxone maintenance therapies have significant limitations. Patients often find themselves dependent on these medications for extended periods, sometimes for life. This dependency can perpetuate a cycle of addiction, making it difficult for individuals to achieve true freedom from opioids. Additionally, these medications can have various side effects, such as drowsiness, constipation, and hormonal imbalances, which can diminish overall quality of life.

The Promise of Ibogaine

Ibogaine, a naturally occurring psychoactive substance derived from the root bark of the African Iboga plant, offers a groundbreaking alternative for treating Methadone and Suboxone dependency. Unlike traditional maintenance therapies, Ibogaine works to reset the brain’s neurochemical balance and addresses the underlying issues that contribute to addiction.


How Ibogaine Works

Interrupting Addiction Pathways

Ibogaine’s primary mechanism of action in treating opioid dependence involves interrupting the addiction pathways in the brain. It has a unique ability to reset the brain’s opioid receptors, effectively reducing cravings and withdrawal symptoms. This resetting process allows individuals to break free from the physical dependency on Methadone and Suboxone, often after just one treatment session.

Noribogaine: Sustained Healing for Methadone and Suboxone Dependence

A crucial component of Ibogaine’s effectiveness is its metabolite, noribogaine. After the initial Ibogaine treatment, noribogaine remains in the body for several months, continuing to work on the brain’s neurochemistry. Noribogaine binds to the same receptors targeted by methadone and Suboxone but without producing the euphoric effects, helping to prevent cravings and withdrawal symptoms. This extended action helps to maintain neurochemical stability and support long-term sobriety.


Scientific Backing

Research has shown that noribogaine’s interaction with the brain’s receptors is crucial for its effectiveness in treating dependence on methadone and Suboxone. Noribogaine acts on the mu-opioid receptor, the serotonin transporter, and the kappa-opioid receptor, among others. These interactions are believed to help manage withdrawal symptoms, reduce cravings, and stabilize mood.

  1. Mu-Opioid Receptor: Noribogaine binds to this receptor, which is also targeted by methadone and Suboxone. However, unlike these medications, noribogaine does not produce significant euphoric effects. This helps in reducing cravings and withdrawal symptoms, facilitating a smoother detoxification process.

  2. Serotonin Transporter: Noribogaine inhibits the reuptake of serotonin, which can lead to increased levels of this neurotransmitter in the brain. Elevated serotonin levels are associated with improved mood and reduced symptoms of depression and anxiety, which are common during withdrawal and recovery from methadone and Suboxone dependence.

  3. Kappa-Opioid Receptor: By modulating this receptor, noribogaine can help in reducing stress and anxiety, which are often heightened during withdrawal periods. This modulation also helps to alleviate dysphoria associated with dependence on these medications.


Long-Term Benefits

The extended presence of noribogaine in the body ensures a sustained therapeutic effect. This prolonged action helps in maintaining neurochemical stability, which is essential for long-term recovery from methadone and Suboxone dependence. Individuals recovering from dependence on these medications often face persistent cravings and psychological challenges. Noribogaine’s prolonged effects can support long-term sobriety by reducing these cravings and improving overall mental health.



  • "Ibogaine and Noribogaine: Differences in Their Mechanisms of Action," Frontiers in Pharmacology.

  • "Noribogaine’s Role in Treating Addiction and Neuropsychiatric Disorders," Journal of Psychopharmacology.

  • "Therapeutic Potential of Noribogaine in Methadone and Suboxone Dependence," Neuropharmacology Reviews.


Neuroplasticity and Healing

Ibogaine promotes neuroplasticity—the brain’s ability to reorganize itself by forming new neural connections. This is achieved through the upregulation of Glial Cell Line-Derived Neurotrophic Factor (GDNF), which supports the survival and growth of neurons. By enhancing neuroplasticity, Ibogaine helps repair the damage caused by long-term opioid use, fostering recovery and mental clarity.

Serotonin and Dopamine Regulation

In addition to its effects on opioid receptors, Ibogaine modulates the brain’s serotonin and dopamine systems. This dual modulation helps restore balance to these critical neurotransmitters, improving mood, reducing anxiety, and alleviating depression. Such comprehensive neurochemical regulation aids in the holistic recovery of individuals, addressing both the physical and psychological aspects of addiction.

Scientific Evidence and Success Stories

Research and anecdotal evidence consistently highlight Ibogaine’s effectiveness in treating opioid dependence, including Methadone and Suboxone. Clinical studies have shown that Ibogaine can significantly reduce withdrawal symptoms and cravings, facilitating a smoother transition to sobriety. Success stories from individuals who have undergone Ibogaine therapy often describe profound psychological insights and emotional healing, which contribute to sustained recovery.

A Comprehensive Approach at MindScape Retreat

At MindScape Retreat, we offer a comprehensive and medically supervised Ibogaine therapy program designed to support individuals in overcoming Methadone and Suboxone dependence. Our approach integrates pre-treatment preparation, personalized Ibogaine dosing, and post-treatment integration, ensuring that every aspect of your healing journey is supported.

The Future of Addiction Treatment

Ibogaine represents a transformative approach to addiction treatment, offering hope to those struggling with dependency on Methadone and Suboxone. By addressing the root causes of addiction and promoting lasting neurochemical balance, Ibogaine paves the way for true recovery and a life free from the constraints of opioid dependency.


Ibogaine’s ability to reset the brain’s opioid receptors, promote neuroplasticity through GDNF upregulation, and regulate critical neurotransmitters like serotonin and dopamine makes it a powerful tool for overcoming Methadone and Suboxone dependence. At MindScape Retreat, we are dedicated to providing safe, effective, and compassionate Ibogaine therapy, empowering our guests to break free from addiction and reclaim their lives.

By choosing Ibogaine therapy at MindScape Retreat, you are taking a courageous step towards a brighter, healthier future. Our experienced team is here to guide and support you every step of the way, helping you achieve lasting recovery and a renewed sense of well-being.

Where will your journey begin?

Ibogaine Treatment 

Ibogaine-assisted therapy at our all-inclusive retreat, staffed with certified doctors, nurses, and US practitioners specializing in Iboga treatments. Situated in Cozumel, renowned as Mexico's safest and most stunning locale, our retreat offers an idyllic backdrop for profound healing and exploration. Includes Psilocybin & 5-MeO-DMT. An all-inclusive experience with every stay

Starting at $7,500

Explore Mexico's holistic anxiety treatment centers

Psilocybin-Assisted Therapy

Experience our 5-day, 4-night psilocybin-assisted therapy retreat, custom-tailored for your unique mental journey. We provide the perfect setting and itinerary for profound exploration and healing. At our retreat, every stay is an all-inclusive experience, featuring snorkeling tours to El Cielo, relaxing beach breaks, cenote visits, and daily explorations across the enchanting Cozumel Island

Starting at $4,000

Tulum's alternative anxiety therapy for relief

5-MeO-DMT (Bufo Alvarius)

Embark on the transformative 5-MeO-DMT journey ("The God Molecule"), a path chosen by many for personal and spiritual growth. This profound experience can significantly enhance your wellness and propel you towards greater mindfulness. At our retreat, we provide diverse options to help you take the next step towards a better, more enlightened self 

Starting at $4,000

Holistic retreats for anxiety in Cancun's paradise
MindScape Retreat Gallery

Our Guests Open
Their Hearts  

"My experience at MindScape Retreat was nothing short of amazing, leading to remarkable personal growth. The doctors and staff were incredibly caring, creating an environment of healing and support."


After my ibogaine treatment at MindScape Retreat, my life has transformed incredibly. Nestled in the serene beauty of Cozumel, the retreat's ambiance is simply delightful, a stark contrast to the bustling Cancún.


Really can’t say enough about how great the experience was and highly recommend them! Went to a clinic before Cancun before and it was more like a hospital. This was a retreat and the attention to detail is great.


bottom of page