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Depression & Anxiety Treatment

Ibogaine Treatment Clinic's pioneering framework for psychedelic-assisted therapy boasts an impressive 98% success rate in alleviating symptoms for individuals grappling with issues such as Depression and Anxiety. Embark on a profound journey of transformation, unlock fresh perspectives on life, and cultivate the art of mindful living at our clinic on the tranquil Cozumel Island, nestled far from the hustle and bustle of Cancun and Tulum.

Advanced Treatment of Depression and Anxiety with Ibogaine Therapy


Understanding Depression and Anxiety

Depression and anxiety are prevalent and severe mood disorders that significantly impact millions of individuals worldwide. Depression is characterized by persistent sadness, loss of interest in previously enjoyed activities, and various cognitive and physical problems. Anxiety involves excessive fear and worry that disrupt daily life. Both conditions often co-occur, leading to substantial impairments in quality of life and functioning.

Challenges of Traditional Treatments

Traditional pharmacological treatments for depression and anxiety, such as Selective Serotonin Reuptake Inhibitors (SSRIs), often provide incomplete relief and are associated with numerous side effects including weight gain, sexual dysfunction, and emotional blunting. Long-term use of these medications can lead to dependency and heightened risks of suicidal ideation, potentially exacerbating the original mental health conditions rather than alleviating them.

Ibogaine: A Novel Therapeutic Approach

Ibogaine, a psychoactive compound derived from the root bark of the African Iboga plant, presents a transformative approach to treating depression and anxiety. Unlike conventional therapies, Ibogaine addresses the underlying causes of these disorders, offering profound healing and long-lasting benefits.

Mechanisms of Action


Neurochemical Rebalancing

Ibogaine operates by resetting the brain's neurochemical balance, particularly affecting neurotransmitters such as dopamine and serotonin, which are essential for mood regulation and emotional stability. This rebalancing can lead to a significant reduction in depressive and anxious symptoms, promoting overall mental well-being.

Neuroplasticity Enhancement via GDNF

Ibogaine's efficacy is partly due to its ability to upregulate Glial Cell Line-Derived Neurotrophic Factor (GDNF). GDNF plays a critical role in neuronal survival and growth, facilitating the brain's capacity to reorganize and repair itself. This enhancement of neuroplasticity is vital for recovering from the neural damage caused by chronic depression and anxiety, thereby supporting long-term mental health improvements.

Sustained Effects through Noribogaine

A pivotal aspect of Ibogaine's therapeutic effect is its metabolite, noribogaine, which remains active in the body for several months post-treatment. Noribogaine binds to serotonin and other neurotransmitter receptors, maintaining neurochemical stability without producing euphoric effects. This sustained activity helps mitigate depressive and anxious symptoms over the long term, providing continuous support for mental health.

Scientific Basis

Research underscores the significance of noribogaine's interaction with various brain receptors in treating depression and anxiety. It impacts the serotonin transporter, mu-opioid receptor, and kappa-opioid receptor, helping manage symptoms and stabilize mood.

Serotonin Transporter

Noribogaine inhibits serotonin reuptake, increasing serotonin levels in the brain, which correlates with improved mood and reduced depression and anxiety symptoms.

Mu-Opioid Receptor

Noribogaine's binding to this receptor aids in symptom reduction without inducing euphoria, facilitating a smoother recovery process.

Kappa-Opioid Receptor

Modulation of this receptor by noribogaine reduces stress and anxiety, common in depression and anxiety disorders, and alleviates associated dysphoria​.

Long-Term Benefits

The extended presence of noribogaine ensures prolonged therapeutic effects, essential for maintaining neurochemical stability and achieving sustained recovery from depression and anxiety. By continuously mitigating symptoms and enhancing overall mental health, noribogaine supports long-term well-being.

Specialized Treatment at MindScape Retreat

MindScape Retreat offers specialized Ibogaine therapy programs tailored to individuals dealing with depression and anxiety. Our comprehensive approach includes pre-treatment preparation, personalized dosing, and post-treatment integration, supported by a dedicated team of professionals to ensure a safe and effective therapeutic experience.

Pre-Treatment Evaluation

Guests undergo thorough evaluations, including medical assessments and psychological screenings, to prepare for Ibogaine therapy.

Personalized Ibogaine Dosing

Our medical team administers carefully calibrated Ibogaine doses, customized to each individual's needs, with continuous monitoring to ensure safety and maximize therapeutic benefits.

Comprehensive Intake Process

Upon arrival, guests receive a detailed intake process involving:

  • Electrocardiogram (EKG): To evaluate heart health.

  • Complete Bloodwork: To assess overall health and identify contraindications.

  • Liver Panel: To check liver function, essential for Ibogaine metabolism


This comprehensive assessment enables our team to develop a safe, personalized treatment plan.

Post-Treatment Integration

Post-therapy, we provide extensive integration support, helping guests process their experiences and apply therapeutic insights to their daily lives, crucial for long-term recovery and personal growth.

Empirical Evidence and Testimonials

Numerous studies and anecdotal reports support Ibogaine's effectiveness in treating depression and anxiety. Research demonstrates significant symptom reduction and neuroregeneration following therapy. Many individuals report transformative experiences, gaining deep insights into their conditions and finding pathways to healing and recovery​.

Future of Depression and Anxiety Treatment

Ibogaine represents a significant advancement in the treatment of depression and anxiety, offering hope to those struggling with these debilitating conditions. By addressing underlying causes and promoting lasting neurochemical balance, Ibogaine offers a pathway to genuine healing and improved quality of life.


Ibogaine’s ability to enhance neuroplasticity through GDNF, sustain therapeutic effects with noribogaine, and facilitate profound psychological insights makes it a powerful tool for managing depression and anxiety. At MindScape Retreat, we are committed to providing effective, compassionate Ibogaine therapy, empowering our guests to reclaim their lives and well-being.

Choosing Ibogaine therapy at MindScape Retreat is a courageous step towards a healthier future. Our specialized programs support overcoming depression and anxiety, helping achieve lasting relief and renewed well-being. Our comprehensive intake process, including EKG, complete bloodwork, and liver panel, ensures safety and prepares you for a transformative healing experience. Our team of doctors and psychologists will work with you to determine the best approach for your unique needs, ensuring a personalized and effective healing journey.

Where will your journey begin?

Ibogaine Treatment 

Ibogaine-assisted therapy at our all-inclusive retreat, staffed with certified doctors, nurses, and US practitioners specializing in Iboga treatments. Situated in Cozumel, renowned as Mexico's safest and most stunning locale, our retreat offers an idyllic backdrop for profound healing and exploration. Includes Psilocybin & 5-MeO-DMT. An all-inclusive experience with every stay

Starting at $7,500

Explore Mexico's holistic anxiety treatment centers

Psilocybin-Assisted Therapy

Experience our 5-day, 4-night psilocybin-assisted therapy retreat, custom-tailored for your unique mental journey. We provide the perfect setting and itinerary for profound exploration and healing. At our retreat, every stay is an all-inclusive experience, featuring snorkeling tours to El Cielo, relaxing beach breaks, cenote visits, and daily explorations across the enchanting Cozumel Island

Starting at $4,000

Tulum's alternative anxiety therapy for relief

5-MeO-DMT (Bufo Alvarius)

Embark on the transformative 5-MeO-DMT journey ("The God Molecule"), a path chosen by many for personal and spiritual growth. This profound experience can significantly enhance your wellness and propel you towards greater mindfulness. At our retreat, we provide diverse options to help you take the next step towards a better, more enlightened self 

Starting at $4,000

Holistic retreats for anxiety in Cancun's paradise
MindScape Retreat Gallery

Our Guests Open
Their Hearts  

"My experience at MindScape Retreat was nothing short of amazing, leading to remarkable personal growth. The doctors and staff were incredibly caring, creating an environment of healing and support."


After my ibogaine treatment at MindScape Retreat, my life has transformed incredibly. Nestled in the serene beauty of Cozumel, the retreat's ambiance is simply delightful, a stark contrast to the bustling Cancún.


Really can’t say enough about how great the experience was and highly recommend them! Went to a clinic before Cancun before and it was more like a hospital. This was a retreat and the attention to detail is great.


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