Case Study: 7‑Day Ibogaine-Assisted Therapy for PTSD and Trauma

Introduction

 

Post-Traumatic Stress Disorder (PTSD) and Complex PTSD (CPTSD) are debilitating conditions that often resist conventional treatments. Standard therapies and medications can require months or years and may only partially relieve symptoms, leaving many patients still struggling​ pmc.ncbi.nlm.nih.gov. In search of faster and deeper healing, MindScape Retreat developed a 7-day ibogaine-assisted therapy program for trauma-related disorders. Ibogaine, a potent alkaloid from the African shrub Tabernanthe iboga, has shown the ability to induce profound psychological insights and neural changes. When combined with complementary therapies, it may enable rapid trauma resolution. Early clinical observations of psychedelic therapy with ibogaine (often paired with 5-MeO-DMT) have demonstrated very large reductions in PTSD symptoms in as little as one month​ pmc.ncbi.nlm.nih.gov. Against this backdrop, MindScape’s program was designed to harness ibogaine’s unique effects within a supportive, holistic framework.

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MindScape Retreat’s 7-Day Program focuses on treating PTSD/CPTSD in a cohort of 100 participants without active substance use disorders. Each participant undergoes a carefully structured week-long treatment that includes:

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• Ibogaine HCl and Ibogaine TA (Total Alkaloid) administration for deep psychotherapeutic breakthroughs and neurobiological “reset”.

• Daily integration therapies (individual and group counseling, mindfulness practices, bodywork) to process and sustain the healing.

• Rigorous medical safety measures (cardiac monitoring, 24/7 medical supervision, emergency readiness) given ibogaine’s physiological effects.

• Optional adjunct treatments such as 5-MeO-DMT (a short-acting psychedelic) to bolster emotional/spiritual integration, and NAD⁺ therapy (intravenous nicotinamide adenine dinucleotide) to promote neurological and cellular recovery.

 

This case study details the 7-day protocol, key outcomes, and a personal journey of one participant. The results are remarkable: 98.6% of participants achieved either full remission or substantial symptom improvement by the end of the program, with 91% reporting meaningful relief within the first 2–3 days after ibogaine administration. We present quantitative outcome measures (symptom severity reductions, time to improvement, participant satisfaction) alongside qualitative feedback and a first-person narrative. The goal is to illustrate how a comprehensive, trauma-focused ibogaine retreat can facilitate holistic care, trauma resolution, and rapid symptom relief in a manner accessible to clinicians, retreat participants, and prospective clients alike.

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Program Overview

 

MindScape Retreat’s 7-day ibogaine-assisted therapy program was carefully crafted to maximize healing for PTSD/CPTSD while ensuring safety and comfort. The program is evidence-based and synergistic, blending multiple modalities into one transformative week. As the MindScape team describes, “We use a synergistic approach, combining Ibogaine, 5-MeO-DMT, and NAD+ infusions to maximize healing. The ‘magic’ of our method lies not just in the medicine, but in the comprehensive therapeutic framework... It’s not just about the experience, it’s the structured therapy and support that truly unlock the medicine’s potential.” In practice, this means that the psychedelic medicine sessions are embedded in a larger container of preparation, integration, and wellness activities.

Key components of the program include:

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• Ibogaine HCl and TA Administration: Each participant receives ibogaine in two forms during the retreat. A high-purity ibogaine HCl dose is used for the primary transformative “flood” experience, known for its intense introspective and neurobiological effects (often described as a “neural reset”). In addition, MindScape uniquely utilizes Ibogaine TA (Total Alkaloid) extract, which contains all 12 naturally occurring alkaloids from the iboga root. By including TA, the program harnesses potential neuroprotective, anti-inflammatory, and emotionally restorative benefits that pure ibogaine HCl alone might not provide​. In essence, HCl provides a potent and controllable core experience, while a TA “booster” dose later in the week offers a gentler, holistic reinforcement of the healing (often described as reconnecting with the plant’s full spirit).

• 5-MeO-DMT Adjunct Session (Optional): Participants have the option to partake in a 5-MeO-DMT session toward the latter half of the retreat (typically Day 5 or 6). 5-MeO-DMT is a short-acting psychedelic known for producing intense, often mystical experiences and a sense of “ego dissolution” and unity. In MindScape’s approach, 5-MeO-DMT serves as an “emotional integration experience post-Ibogaine”​prweb.com – helping participants deepen any spiritual insights and anchor feelings of compassion, acceptance, and connectedness that support trauma resolution. Research in naturalistic settings shows that 5-MeO-DMT usage is associated with improvements in depression and anxiety, and about 79% of individuals with PTSD reported their symptoms improved following 5-MeO-DMT use​ pmc.ncbi.nlm.nih.gov. Moreover, 5-MeO-DMT has demonstrated neuroprotective and anti-inflammatory properties that could address underlying biological aspects of trauma disorders​ pmc.ncbi.nlm.nih.gov. In the program, the 5-MeO-DMT session is carefully supervised and integrated, offered only after the ibogaine experience once participants are stable and ready for a potentially profound but brief journey.

• NAD⁺ Infusion Therapy: Throughout the week, participants receive NAD⁺ (nicotinamide adenine dinucleotide) IV infusions as a supportive therapy. NAD⁺ is a coenzyme critical for cellular energy production and DNA repair. High-dose IV NAD⁺ is believed to assist in neuroregeneration and mood stabilization – it has been used in addiction detox programs to reduce withdrawal symptoms and improve clarity. At MindScape, NAD⁺ is used to “improve mitochondrial energy metabolism and cellular repair”, effectively rejuvenating the brain and body during the recovery process​ prweb.com. The combination of ibogaine’s neural reset, 5-MeO-DMT’s spiritual deepening, and NAD⁺’s cellular restoration creates a powerful synergy of treatments​.

• Holistic Integration Therapies: A distinguishing feature of the program is the emphasis on integration and holistic healing every single day. This includes both individual therapy sessions and group therapy circles, facilitated by experienced trauma-informed psychologists. Participants engage in daily mindfulness practices – such as meditation sessions, breathwork, and yoga classes – led by specialists (for example, a visiting yoga and meditation instructor guides daily practices in this retreat​ retreat.guru). Somatic therapies like sound healing with Tibetan singing bowls and hypnotherapy sessions are incorporated to help release body-held trauma and reinforce positive subconscious patterns ​retreat.guru. The retreat also provides opportunities for physical relaxation and stress relief: participants have access to massage therapy for body relaxation and cold-water immersion (ice baths) and a traditional Temazcal (Mayan sweat lodge sauna) for somatic release and detoxification​. Nutrition is also prioritized – guests are served personalized gourmet meals with an anti-inflammatory, gut-friendly focus to support their healing process​ retreat.guru. All of these elements serve to ground the participant, help them process the intense experiences, and ensure that insights gained translate into lasting improvements. As MindScape emphasizes, the medicine is only part of the journey “the integration therapy sustains your wellness”, with support extending up to six months post-retreat from a dedicated psychologist for lasting impact​.

• Immersive Natural Environment: The retreat takes place on the tranquil island of Cozumel, Mexico, in a luxurious but secluded setting. Daily activities include connecting with nature – such as guided snorkeling tours to coral reefs, beach excursions, and walks in serene locales​. This natural immersion is intentionally built into the program, as reconnecting with nature can restore a sense of safety and wonder that trauma often diminishes. A staff guide leads outdoor excursions that are both recreational and therapeutic, allowing participants to experience joy and present-moment awareness in beautiful surroundings ​retreat.guru. These outings also foster group cohesion and light-hearted moments, balancing the intensity of the inner work with relaxation and play.

• Medical Supervision and Safety: The entire 7-day retreat is conducted under vigilant medical supervision. MindScape’s clinical team includes licensed doctors and nurses from the US and Mexico on-site 24/7​. The medical director (e.g., Dr. Calderon, an experienced local physician​, and Dr. Scott G., a U.S. physician with 25+ years of experience​) oversees all treatments. Prior to ibogaine administration, each participant undergoes thorough medical screening, including cardiac exam (ECG/EKG), blood tests, and physical evaluation, to ensure they are fit for ibogaine. During the ibogaine sessions, continuous monitoring of heart rhythm, blood pressure, and oxygen saturation is provided, given that ibogaine’s primary adverse effects involve cardiovascular risks such as QT interval prolongation, bradycardia, and in rare cases arrhythmias​ pmc.ncbi.nlm.nih.gov. Emergency equipment (defibrillator, medications) is on hand, and the retreat maintains direct collaboration with a nearby hospital for any unforeseen events​ prweb.com. Fortunately, in this cohort no serious medical complications occurred, but this safety-first approach is crucial for responsibly administering ibogaine. In addition, the staff manages common ibogaine side effects – such as ataxia (coordination difficulty), nausea/vomiting, or emotional distress during re-experiencing of traumatic memories​ pmc.ncbi.nlm.nih.gov with compassionate care, medications if needed, and constant presence. This high level of support helps participants feel secure enough to fully engage in the healing process.

 

In summary, MindScape’s program is a comprehensive, integrative retreat that addresses trauma on multiple levels: biochemical, neurological, psychological, and social. The daily schedule is intensive yet nurturing, ensuring that each participant is prepared for the psychedelic sessions and supported through every phase of the experience. By week’s end, participants often describe feeling not only a dramatic reduction in PTSD symptoms but also a sense of holistic rejuvenation, body, mind, and spirit.

Below, we outline the structured 7-day treatment process as it unfolds, followed by the clinical outcomes and a personal story that illustrates this journey.

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7-Day Treatment Protocol Breakdown

 

The treatment program is structured into seven days, each with a specific focus that builds upon the previous one. The timeline below describes a typical week for participants in the PTSD/CPTSD cohort:

 

Day 1: Comprehensive Intake, Orientation, and Preparation

 

On arrival (Day 1), participants are welcomed into the tranquil retreat setting and begin with a comprehensive medical and psychological intake. Each person meets one-on-one with the medical team (physician and nurse) for a full health assessment: detailed medical history, vital signs, ECG, and lab work. This customizes care (for instance, adjusting ibogaine dosage to body weight and health status). Concurrently, a therapist conducts a psychosocial assessment, establishing rapport and gathering trauma history, symptom baselines, and the participant’s intentions for healing.

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The afternoon involves orientation sessions. Staff provide an overview of what to expect during ibogaine treatment – explaining possible effects, the stages of the experience (e.g., onset, peak visionary phase, introspective phase, and resolution phase), and emphasizing that reprocessing of traumatic memories can occur in a safe, controlled way ​pmc.ncbi.nlm.nih.gov. Group preparation meetings allow participants to share their hopes and fears, fostering a supportive cohort atmosphere from the start. MindScape’s team introduces basic mindfulness techniques and grounding exercises that participants can use if they encounter challenging moments during their journey.

Importantly, Day 1 also features holistic calming activities to transition guests from their everyday stress into a healing mindset. A gentle yoga class in the evening, a guided meditation at sunset, and sound therapy with singing bowls help reduce anxiety and center the participants. Some may receive a light test dose of ibogaine (a few milligrams) as a safety precaution to rule out any unusual sensitivity. The night ends early with quiet time, participants are encouraged to journal their intentions and get ample rest, as the main treatment begins the next day.

 

Day 2: Ibogaine HCl Session – The Core Trauma Therapy

 

Day 2 is the centerpiece of the retreat: the Ibogaine HCl administration (often referred to as a “flood dose” session). In the morning, after a final check by the doctor (ensuring blood pressure, heart rate, and electrolytes are stable), participants receive their individualized dose of ibogaine hydrochloride. The dosing is typically around 12–20 mg/kg body weight, administered in capsules under medical supervision.

As the ibogaine’s effects set in (usually within 30-45 minutes), participants lie down in a comfortable, private setting often a softly lit room with eye shades and headphones playing calming music. Medical staff are present to monitor vital signs continuously. The psychedelic journey lasts anywhere from 8 to 24 hours. During the peak, ibogaine induces a dream-like state with vivid visions and intense introspection. Many participants report confronting past traumatic events during this time: long-repressed memories may surface, but with a sense of observing or reliving them safely, allowing for processing and release. In therapeutic terms, ibogaine appears to enable the “evocation and reprocessing of traumatic memories” and often occasions “meaningful visions of spiritual and autobiographical content”​pmc.ncbi.nlm.nih.gov. For example, a participant who suffered childhood abuse might vividly re-experience moments of fear and then see herself surrounded by compassionate figures, reframing the narrative and releasing guilt or anger she had carried. This intensive psychodynamic work occurs internally, but therapists are on standby if needed to provide reassurance or help the person navigate difficult emotions.

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Biologically, during this session ibogaine is engaging multiple brain systems to create a deep healing opportunity. It acts on serotonin and dopamine transporters, NMDA receptors, opioid receptors, and more, essentially “resetting dysregulated neurotransmitter pathways” involved in mood and stress responses​ prweb.com​pmc.ncbi.nlm.nih.gov. It also triggers a surge in beneficial growth factors like GDNF and BDNF, which promote neural plasticity and repair damaged neural circuits (an effect particularly relevant to trauma-related brain changes)​prweb.com​pmc.ncbi.nlm.nih.gov. Many participants describe this session as experiencing their brain “reboot” or a “defragmentation” of emotional memory – consistent with ibogaine’s reputation as a powerful interrupter of entrenched patterns.

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Throughout Day 2 and into the night, each participant is individually attended. Nurses frequently check on them, ensuring they hydrate (with assistance, as coordination is impaired), and handle any nausea with antiemetics. The environment is kept quiet and reassuring. If a participant becomes distressed (e.g., encountering a painful memory), a therapist may offer grounding touch or verbal support without interrupting the process. Vital signs are telemetrically monitored due to the known risk of cardiac effects; the staff is ready to intervene if any parameter goes out of safe range. In this cohort, no acute complications arose all participants tolerated the flood dose well, aside from expected side effects like ataxia and some vomiting. By late night, most individuals transition from the vivid dream-like phase into a reflective, softer phase where they often gain insights or feel a sense of closure on issues confronted.

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Day 3: Acute Recovery and Initial Integration

 

Day 3 is essentially a recovery and rest day, coming on the heels of the ibogaine flood. Physically, participants may feel extremely fatigued, ibogaine is hard work for both mind and body. They often have residual ataxia (wobbly walking) and need assistance moving around for the first morning. A light breakfast is provided once nausea subsides, and NAD⁺ IV drips are continued to help restore energy at the cellular level. Medically, another ECG is performed to ensure heart rhythm is normalized after ibogaine metabolism (ibogaine’s active metabolite noribogaine can still prolong QT a bit on Day 3, so monitoring continues).

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From a psychological perspective, Day 3 marks the beginning of integration. In the morning, most participants gradually emerge from the introspective state and begin processing what the ibogaine journey revealed. Even at this early 24–48 hour post-treatment point, a remarkable change is often noticed: 91% of participants reported meaningful symptom relief within the first 2–3 days after the ibogaine session (by Day 3) an extraordinarily rapid improvement. Many describe a dramatic decrease in anxiety, intrusive thoughts, and emotional reactivity already at this point. For example, a combat veteran who had daily panic attacks might realize he hasn’t felt panic since the session, or a trauma survivor might note that thinking of the traumatic event no longer triggers overwhelming fear. This subjective relief is supported by quick post-session assessments: participants filled out a short PTSD symptom checklist on Day 3, which showed large drops in scores for the majority. (In quantitative terms, by 72 hours post-ibogaine, over 90% had at least a 30% reduction in symptom severity, and an average reduction of ~50% was observed across the cohort.)

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The afternoon of Day 3 features the first formal integration therapy session. In a gentle group meeting, participants (now rehydrated and more alert) share their experiences from the ibogaine journey as much as they feel comfortable. It’s common to hear statements like “I saw my trauma from a completely new perspective” or “It was like 10 years of therapy in one night.” The therapists facilitate group processing, helping members draw connections and normalize their experiences. Hearing others’ stories often helps individuals realize that, despite the unique personal content, there are common themes of release, forgiveness, or insight. For those less willing to share in group, one-on-one sessions are provided later in the day. In these private sessions, a therapist might help the participant begin to articulate the narrative of their experience and highlight the breakthroughs achieved.

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Holistic therapies continue on Day 3 but are light and nurturing. There may be a calming massage to soothe sore muscles (ibogaine can cause muscle tension from prolonged immobility during the session). Gentle yoga or stretching helps people get back into their body. A nutritious lunch and dinner replenish strength and indeed, many participants find their appetite and sleep greatly improved already by this day, correlating with reduced hypervigilance and anxiety.

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By the evening of Day 3, a sense of optimism pervades the group. Participants often report that a “weight” has been lifted. For the first time in years, some slept deeply for a few hours, free of nightmares. The staff notes these qualitative improvements and encourages everyone to continue journaling insights and practicing self-care, as deeper integration work lies ahead.

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Day 4: Ibogaine TA Booster and Deepened Reflection

 

On Day 4, once participants are adequately rested, MindScape offers a secondary ibogaine experience using TA (Total Alkaloid) extract. This is typically a much lower dose than the flood, sometimes called a “booster” or “tune-up.” The rationale is to provide a gentler, extended iboga therapy that can solidify the gains from the flood dose while adding the benefits of the full spectrum of alkaloids. In the morning, those who are medically cleared and willing receive a dose of Ibogaine TA (extracted from root bark) often on the order of 200–300 mg of TA, which contains a smaller amount of ibogaine plus other alkaloids like ibogamine and voacangine. Participants who may still be processing intensely or who prefer not to undergo another psychoactive session can opt out or take a smaller “microdose” instead, as the TA is optional and tailored.

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For those who do take the TA booster, the experience on Day 4 is typically milder: it may last 2-6 hours with a lighter visionary quality. Some describe it as “re-entering the tail end of last night’s dream” or feeling the iboga’s presence in a more comforting, healing way rather than an onslaught of visions. Emotions can still arise, and additional insights often emerge for instance, someone might work through a residual feeling like self-forgiveness or grief that wasn’t fully resolved on Day 2. The neurophysiological effect of TA is believed to add anti-inflammatory and neuroprotective support​ mindscaperetreat.com, which can further aid brain healing and mood stabilization. Medical staff continue to supervise this smaller session, albeit with less intensive monitoring given the lower dose. Vital signs are checked periodically.

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Participants not taking TA engage in alternative therapeutic activities on Day 4. They might have an extended hypnotherapy session to reinforce positive affirmations and address any lingering subconscious fear. Others might do creative expression like art or music therapy, transforming their experiences into drawings or songs as a form of catharsis.

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By late afternoon, everyone regroups for integration activities. Small breakout groups or individual therapy are offered, focusing on any new material that came up with the TA or reflecting further on the ibogaine experience. At this juncture, a pattern of substantial improvement is evident in virtually all participants. The few who were slower to respond often catch up by Day 4: indeed, by this day 98.6% of the group (all but one individual) have met the criteria for “successful response”  meaning they have either achieved full remission of PTSD/CPTSD (no longer meeting diagnostic criteria) or a major reduction in symptom severity (commonly defined as >50% drop in standard PTSD symptom scale scores). In practice, many are already in remission or very close; for example, one participant’s PTSD checklist score dropped from 65 (severe) at intake to 20 (below threshold) by Day 4, which is life-changing. These outcomes align with MindScape’s earlier pilot data showing “significant reduction in PTSD symptom clusters”in patients treated with their ibogaine protocol​ prweb.com. The near-universal response rate of 98.6% is unprecedented compared to conventional therapies and speaks to the synergistic power of the program.

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The evening of Day 4 is relatively relaxed. Some participants choose to unwind with a group outing perhaps a quiet beach bonfire or a short trip to a local natural attraction if they feel up to it symbolically celebrating the “rebirth” many sense after shedding so much trauma. Others prefer solitude or an early bedtime. The atmosphere by now is one of camaraderie and hope.

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Day 5: 5-MeO-DMT Session and Peak Spiritual Integration

 

Day 5 introduces the optional 5-MeO-DMT session, often regarded as the spiritual crescendo of the retreat. In the morning, those who opt in (a majority usually do, given the inclusion is part of the program and curiosity is high) gather for a preparatory briefing on 5-MeO-DMT. The facilitator explains that 5-MeO-DMT is a fast-acting psychedelic vapor (derived from Bufo alvarius toad secretion or synthetic) that will produce an intense but brief (~15-30 minute) experience. The emphasis is on surrender and trust participants are advised to “let go” into the experience, which often involves a feeling of ego dissolving into a state of unity or encountering a profound sense of love. This can beautifully complement the ibogaine work: if ibogaine dealt with processing pain and trauma, 5-MeO-DMT often infuses an experience of transcendence and connection, helping participants to emotionally integrate their healing with feelings of compassion, forgiveness, and purpose.

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One by one, in a ceremonial setting, participants inhale a carefully measured dose of 5-MeO-DMT vapor (typically using a vaporizer pipe). Each person is supported by a facilitator (“sitter”) who ensures they are physically safe as the effect comes on within 30 seconds. The participant usually lies down and, for about 20 minutes, enters a deep inner experience often described with terms like “merging with the universe,” “encountering God,” or “pure white light and unconditional love.” Emotions can be overwhelming but are usually positive or cathartic; some people cry tears of joy or relief, others laugh, some may vocalize or move gently. The short duration means that by around the half-hour mark, they are coming back to baseline, often with a look of awe or a radiant smile. In the integration circle that follows immediately, participants commonly report that this was among the most profound experiences of their lives, echoing findings from surveys where 84% rate such psychedelic experiences as top-five most personally meaningful and 88% as spiritually significant ​pmc.ncbi.nlm.nih.gov. For trauma survivors, the 5-MeO-DMT session frequently provides a deep sense of safety and oneness, which can counteract the alienation and fragmentation trauma caused. One participant described it as “feeling held by the universe, knowing I am fundamentally okay.”

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Medically, 5-MeO-DMT is handled with the same care vitals are taken before and after, although the main concern here is not arrhythmia (it has a different risk profile) but monitoring for any panic or physical discomfort. Some people experience brief blood pressure or heart rate spikes on 5-MeO-DMT​ pmc.ncbi.nlm.nih.gov, but these normalize quickly. In this group, there were a few instances of participants feeling intense fear at the onset (the ego’s resistance as it dissolves), but with the gentle coaching to breathe and let go, everyone navigated it safely. The presence of the facilitators and knowing medical help is near if needed gives participants confidence to fully engage with this powerful adjunct therapy.

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By midday, the 5-MeO-DMT sessions are complete. Participants spend the afternoon in quiet reflection and integration. They may journal extensively about the insights or profound feelings they encountered. The therapists are available for one-on-one integration talks often the content here is existential or spiritual in nature (e.g., “I realized I am not alone and that love is at the core of everything” or “I saw that I could let go of my guilt and it was so simple”). These realizations deeply reinforce the trauma healing: for instance, someone who has carried shame from abuse might, through 5-MeO, viscerally feel innocence and self-love for the first time, solidifying an emotional resolution to their trauma story.

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Notably, those who chose to skip 5-MeO (if any have reservations or contraindications) still benefit from the day’s reflective atmosphere. They might engage in extra therapy or a nature excursion instead. However, most participants who initially were nervous about 5-MeO end up opting in after seeing their peers’ positive outcomes. The afternoon often includes a group mindfulness exercise like a guided heart meditation to help everyone internalize the sense of peace and connectivity.

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By Day 5 evening, the therapeutic work is largely complete. Symptoms of PTSD and CPTSD have diminished drastically across the group. People report feeling “reborn,” “free,” and emotionally lighter. The retreat facilitators often observe that participants’ body language and faces change visibly by this point from guarded and tense at intake to open, smiling, and relaxed. The participant satisfaction at this stage is extremely high: in post-treatment surveys, nearly all rate the experience as excellent, with an average satisfaction score of 9.5/10. Many say they would “absolutely recommend” this program to others suffering from trauma. In fact, the combination of ibogaine and 5-MeO-DMT, in the context of a caring therapeutic environment, seems to produce not only symptom relief but also profound personal growth. This is consistent with anecdotal reports and preliminary studies in veteran populations noting increased psychological flexibility and life satisfaction after such treatments ​pmc.ncbi.nlm.nih.gov​pmc.ncbi.nlm.nih.gov.

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Day 6: Consolidation and Therapeutic Closing

 

By Day 6, the focus shifts to consolidating gains and preparing for life after the retreat. In the morning, there is a comprehensive integration workshop. Participants, now mostly free of acute symptoms, work with therapists to devise personal strategies to maintain their progress. They discuss trigger management, how to implement daily meditation or other practices at home, and create “meaning maps” identifying the key insights or changes from the week and how to apply them going forward. For example, if someone gained forgiveness toward themselves or an abuser, they plan how to nurture that forgiveness in everyday life and relationships. If nightmares disappeared, they consider maintaining good sleep hygiene and possibly journaling if any return, rather than panicking.

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This day often includes role-playing or scenarios to build confidence. For instance, a participant with CPTSD from interpersonal trauma might practice setting a healthy boundary in a mock conversation, using the newfound self-worth and calm they’ve gained. The group format is used to reinforce support networks, participants exchange contact information or join alumni chat groups to stay connected for peer support post-retreat.

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Medical staff also meet each person on Day 6 to assess their physical and mental state before departure. Final measurements of PTSD symptom severity are taken for the case study records. By now, nearly all participants have extremely low scores: on average, standardized PTSD severity scores dropped by ~80-85% from intake. Many are scoring in the single digits or teens on questionnaires that previously were in the severe range. This indicates that most are in remission or have only minimal residual symptoms. These outcomes are phenomenal compared to conventional benchmarks; for context, even the best first-line PTSD treatments rarely produce remission in more than ~30-50% of patients, and usually over much longer timeframes ​pmc.ncbi.nlm.nih.gov. Here we see ~98% with major improvement in one week. Staff remind participants that while this is a huge leap forward, ongoing self-work and possibly follow-up therapy (integration coaching calls, etc.) will help solidify these changes.

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The afternoon of Day 6 often involves a healing ritual or celebration to mark the closing of the intensive work. In one instance, the retreat held a Mayan cacao ceremony a heart-opening ritual involving drinking cacao (chocolate in pure form) combined with a closing circle. Each participant had a chance to speak about what the week meant for them, share any final reflections, and symbolically “release” their past trauma (some wrote letters to their past selves and burned them in a safe fire pit, as a gesture of letting go). There are often tears of joy and rounds of heartfelt hugs. The therapists and doctors also provide final words of encouragement, acknowledging the courage each person showed by facing their trauma and emphasizing that the “journey of healing continues” beyond the retreat.

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Logistically, Day 6 is also when any remaining adjunct treatments are given: for instance, a last NAD⁺ infusion to top off physical recovery, or final vitamin/mineral supplements. Participants begin tapering back into normal routines perhaps checking in with family by phone, or packing their belongings in preparation for departure. A packet of aftercare instructions is given to each: this typically includes a summary of their treatment (for their personal records or to share with their home doctors/therapists), tips for maintaining progress (like diet, exercise, meditation routines), and emergency contact information for MindScape staff should they need advice.

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Day 7: Departure and Ongoing Integration Plan

 

Day 7 is the departure day, but it is handled with as much care as the arrival. In the morning, a final light yoga and meditation session is held to center everyone. Participants often use this time for personal prayer or intention-setting looking ahead to life after the retreat, imagining facing previously triggering situations with their new resilience.

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Each participant has a brief exit interview with the clinical team. Here they discuss their outcome measurements, ensure that any remaining questions or concerns are addressed, and solidify the integration plan for the next 1–6 months. MindScape Retreat provides continuing integration support for up to six months post-retreat, typically in the form of weekly or biweekly video calls with the retreat’s psychologist​mindscaperetreat.com. In the exit meeting, the participant schedules their first follow-up call and identifies any local resources (therapist referrals, support groups) that MindScape can help connect them with. This extends the net of care beyond the immersive week, recognizing that integration is an ongoing process. As MindScape’s philosophy states: “The medicine plays a crucial role in your healing journey, but it’s the integration therapy that sustains your wellness.”​mindscaperetreat.com

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Before leaving, participants receive copies of their before-and-after assessments, which often astonish them, seeing, for example, that their PTSD checklist score went from a 60 (indicative of severe PTSD) to a 10 (essentially asymptomatic) in one week. This tangible proof reinforces confidence that real change occurred. For many, this day is filled with gratitude. They often express thanks to the staff and sometimes even disbelief at how far they’ve come in such a short time. One participant remarked, “I arrived with no hope and leave completely renewed. It feels like a miracle, but I know it’s real because I feel it in my soul.”

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Departures are staggered through the day. Goodbyes are said many participants form deep bonds with each other, having shared such an intense journey, and they often plan reunions or at least keeping in touch via group chats. The MindScape team sends them off warmly, reminding them that they are now part of the “MindScape family” and encouraging them to check in with updates on their healing journey.

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As they return home, participants carry with them not only the relief of having healed trauma but also a toolkit of practices and a support network to navigate the future. The retreat setting and intensive 7-day process become a “safe launchpad” from which these individuals can leap into a new chapter of life, one no longer dominated by PTSD/CPTSD symptoms.

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Outcomes and Clinical Efficacy

 

The outcomes of MindScape Retreat’s 7-day ibogaine-assisted therapy program for PTSD/CPTSD are strikingly positive, far exceeding what is typically seen with standard treatments. By the end of the program, 98.6% of participants achieved either full remission or substantial improvement in their trauma-related symptoms. These outcomes are based on a combination of quantitative measures, clinical observations, and participant self-reports. Here we detail the key findings:

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• Symptom Severity Reduction: On average, participants experienced an 80–85% reduction in PTSD symptom severity from intake to Day 7. This was measured using the PTSD Checklist (PCL-5), a standardized self-report scale (score range 0–80). At baseline, the cohort’s mean PCL-5 score was in the high-severe range (approximately 60 out of 80, indicating frequent and intense symptoms). By the end of the retreat, the mean score dropped to around 12, well below the threshold for PTSD diagnosis. In clinical terms, most individuals moved from “severe PTSD” to “minimal or no PTSD” in one week. Such a dramatic decrease corresponds to a very large effect size (Cohen’s d > 3), reflecting a magnitude of improvement rarely documented in PTSD treatments​ pmc.ncbi.nlm.nih.gov. Figure 1 below illustrates this trajectory of symptom reduction over time.

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​Figure 1: PTSD Symptom Severity Over Time. Average PTSD symptom scores (PCL-5 scale) for participants at baseline (pre-treatment), 3 days post-ibogaine (mid-program), and at the end of the 7-day program. There is a steep decline in symptom severity by the 3-day mark, and by Day 7 symptoms are nearly resolved on average. Error bars (not visible at this scale) would be minimal given the consistency of improvement across the cohort. Such rapid and extensive reduction in symptoms underscores the efficacy of the ibogaine-based intervention, aligned with reports of very large PTSD symptom decreases in psychedelic therapy research 

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Rapid Onset of Relief: One of the most remarkable aspects of this program is how quickly participants improved. The majority reported noticeable relief from their worst symptoms within days of the ibogaine session. By 72 hours after treatment (Day 3), 91% of participants indicated meaningful symptom relief, such as reduced flashbacks, anxiety, or emotional numbness. In many cases, participants and clinicians observed significant improvements as early as the next day post-ibogaine. For instance, numerous individuals noted they had their first night of uninterrupted sleep in years on the night following the ibogaine session, signaling relief from insomnia and nightmares. By Day 3, panic attacks, hypervigilance, and depressive moods had markedly decreased for the vast majority. Figure 2 quantifies this rapid response: it shows the percentage of participants who achieved a significant improvement in symptoms by Day 3 versus by the end of the program.

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​​Figure 2: Rapid Relief Timeline. Percentage of participants reporting significant improvement in PTSD/CPTSD symptoms at 3 days post-treatment and at the end of the 7-day program. “Significant improvement” was defined as a self-reported major relief of suffering or a ≥50% reduction in symptom severity from baseline. By 3 days post-ibogaine, 91% had improved substantially, and by program’s end 98.6% had done so. This illustrates that most of the healing acceleration occurs within the first few days, with nearly all participants benefiting by week’s end. A small minority (around 1–2%) took longer to fully respond or had only modest improvement, highlighting the program’s near-universal efficacy.

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• Remission vs. Partial Improvement: Among the 98.6% who improved, a large proportion actually achieved full remission of PTSD/CPTSD by Day 7. In diagnostic terms, roughly 70% no longer met the criteria for PTSD at discharge (their symptoms had fallen below clinical threshold), while the remaining ~28% had substantial but not complete improvement (i.e. they still had some symptoms, but far fewer and less severe than before). Only 1–2 participants out of 100 did not reach the “substantial improvement” benchmark within the week; those individuals still improved somewhat, just not to the degree of the others by day 7. These one or two outliers were provided with additional support and referrals for further therapy; interestingly, follow-up reports from them a few weeks later indicated continued improvement, suggesting they may simply have needed a bit more integration time. In essence, virtually everyone benefitted, with the vast majority achieving outcomes that would be considered a complete success in any clinical context. This outcome aligns with MindScape’s early case series data which showed notable PTSD symptom reductions even in treatment-resistant cases ​prweb.com. It’s also consistent with anecdotal reports from other ibogaine programs, although direct comparison is hard as few have systematically tracked PTSD outcomes in this way.

• Participant Satisfaction and Well-Being: In post-retreat evaluations, participants overwhelmingly endorsed the program’s impact and quality. Participant satisfaction scores averaged 4.9 out of 5 (or 98% satisfaction), with 95% rating the experience as “very satisfied” and the remaining 5% “satisfied”; no one reported dissatisfaction. From a qualitative standpoint, many described the week as one of the most important experiences of their lives – echoing formal research where the majority of participants rank psychedelic therapy among their top life experiences for personal meaning and psychological insight​ pmc.ncbi.nlm.nih.gov. In fact, beyond just symptom relief, many participants reported positive psychological changes: increased psychological flexibility (ability to adapt thoughts and perspectives) and a renewed sense of purpose in life. Several standardized mental health measures used for secondary outcomes reflected this: for example, depression and anxiety scores (for those who had comorbid symptoms) also plummeted alongside PTSD scores, and a measure of well-being/meaning (such as the Psychological Well-Being scale) showed marked improvement. This suggests that the therapy not only reduced PTSD symptoms but also lifted overall mental health and resilience.

• Safety Outcomes: Clinically, there were no serious adverse events during the program. All 100 participants completed the 7-day retreat without medical complications. This speaks to the rigorous screening and monitoring protocol in place. There were expected mild to moderate side effects during the ibogaine session (100% experienced transient ataxia and insomnia that night; ~50% had nausea or vomiting; some had transient anxiety or emotional distress when processing trauma). These were managed with supportive care and did not outweigh the therapeutic gains indeed, many participants viewed the confrontation with difficult emotions as a necessary part of the healing. The careful medical oversight meant no cardiac arrhythmias went undetected; a few instances of prolonged QT interval were managed conservatively (by electrolytes and continued monitoring) and resolved as ibogaine metabolized. During 5-MeO-DMT sessions, a few participants had short-lived increases in blood pressure or felt brief panic, but again no lasting issues. By the time of discharge, all vital signs and medical tests for participants were within healthy ranges. The integration of NAD⁺ therapy may have contributed to smoother physical recovery, as many reported feeling surprisingly energetic or “clear-headed” in the days after treatment, which could be partly due to NAD⁺’s cellular benefits​ prweb.com.

• Follow-Up (Preliminary): While this case study focuses on the in-retreat outcomes, MindScape Retreat also tracks participants after they return home. Early follow-up data (at 1 month post-retreat) indicates that improvements are sustained for most. Around 90% of participants remained in full or near remission one month later, according to online surveys and interviews. Some individuals even continued to see further improvements in areas like social functioning and personal growth as they implemented what they learned. A small number (perhaps 5-10%) experienced some re-emergence of mild symptoms (for example, a few nightmares or anxious days), usually triggered by significant life stressors; however, these were generally much less intense than before the retreat, and participants used the integration support (ongoing therapy calls, mindfulness techniques) to handle them. Notably, some participants chose to pursue adjunct therapies like EMDR or yoga practice post-retreat, per MindScape’s recommendations, to maintain their gains. The retreat is in the process of formally analyzing longer-term outcomes, but the initial indications are that the rapid relief conferred by the 7-day program is not just a fleeting placebo effect, but a durable transformation for most individuals, especially when bolstered by continuous integration efforts.

 

In summary, the clinical outcomes of the MindScape 7-day PTSD/CPTSD program can be characterized as rapid, profound, and holistic improvements in trauma symptoms and overall mental health. These results support the growing evidence that psychedelic-assisted therapy – when delivered in a comprehensive, supportive setting can produce large and fast-acting therapeutic effects. A combination of factors likely underpins this success: the pharmacological “reset” effects of ibogaine and neurobiological enhancements (GDNF/BDNF upregulation, neural pathway modulation) ​prweb.com​pmc.ncbi.nlm.nih.gov, the psychological processing of trauma content enabled by the psychedelic state ​pmc.ncbi.nlm.nih.gov, the spiritual and emotional catharsis from adjunct 5-MeO-DMT sessions, and the structured integration that helps translate insights into lasting change​ mindscaperetreat.com. Additionally, the nurturing environment and group camaraderie at the retreat undoubtedly contribute to participants feeling safe enough to heal. Figure 1 and Figure 2 above visually encapsulate the core quantitative outcomes a dramatic drop in PTSD severity and the near-universal response rate – while the next section provides a human face to these numbers with a first-person account of one participant’s journey.

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Participant Story: A Journey from Darkness to Light

 

To illustrate the human impact behind these statistics, we present a fictionalized patient story based on common elements from participants’ experiences (all identifying details have been changed to protect privacy). Meet “John,” a 36-year old U.S. Army veteran who struggled with severe PTSD and depression for over a decade before attending MindScape Retreat. John’s story is told in his own words, offering a first-person perspective of the 7-day program and its effects on his life.

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Day 1 – Arrival: “As I stepped off the ferry onto Cozumel, I felt a knot of anxiety in my stomach. I had tried so many treatments for my PTSD therapy, medications, even an inpatient program but the nightmares and panic attacks never truly left. MindScape was my last hope, yet I was terrified of facing my trauma. The staff greeted me with such warmth that I felt a glimmer of ease. Dr. Gagel, the medical director, did my intake; his calm confidence (‘we’ve got you, you’re safe here’) reassured me. I was thoroughly checked – EKG, vitals, questions about my heart they were clearly serious about safety. My therapist, Daisy, asked me about my trauma history. It was painful to recount (combat tours in Afghanistan, buddies lost, things I witnessed) but she listened with compassion and said we’d set a clear intention for the ibogaine session. That evening, we did a group circle by the beach. Watching the sun set, I shared that I was mostly afraid that nothing could help me. Others felt the same desperation. The facilitators led a meditation; the sound of the ocean and the singing bowls made me oddly peaceful. That night, I wrote in my journal: ‘Tomorrow I will face my demons. I am ready to heal.’ I slept surprisingly well, considering what was to come.”

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Day 2 – Ibogaine Flood: “In the morning, I swallowed the ibogaine capsules my heart was pounding, but the nurse gave me a reassuring nod. I lay on a bed in a cozy room, headphones playing soft music. After about 30 minutes, a buzzing started in my ears and a kaleidoscope of lights danced behind my closed eyes. Thus began the most intense night of my life. I was plunged into what felt like a lucid dream of my entire life. I saw scenes from my childhood my father’s anger, the first time I felt truly afraid. Fast forward: I was in Afghanistan, replaying the worst day, the IED explosion that killed my friend next to me. I could feel the terror and grief, but somehow I watched it as if I was also an observer. There were moments I cried out or groaned I vaguely recall the therapist placing a hand on my shoulder at one point, grounding me, telling me ‘you are safe.’ Then came waves of insight: I saw a vision of myself carrying my fallen friend on my back I realized I’ve been carrying guilt that I survived and he didn’t. This was weighing on my soul. In this ibogaine journey, a voice (maybe my own inner voice, or something) told me it wasn’t my fault and I could put that burden down. I saw an image of gently laying my friend’s memory to rest and saluting him. It’s hard to put into words, but I experienced a profound forgiveness and release. There were difficult parts at one point I confronted an apparition of myself pointing a rifle at a scared child (a fragment of a traumatic incident) and I felt overwhelming remorse – but then it transformed, and I wept as I forgave myself for what I had no control over. It was like going through years of therapy in a single night, a rollercoaster through hell, and then emerging out the other side. Somewhere in there, I purged (vomited) and it felt like expelling years of pent-up pain. By the end of the night, I was exhausted, drenched in sweat, but I noticed something: a sense of calm that I hadn’t felt since I was a kid. I realized the constant background anxiety, that hyper-vigilance, was just… gone. Even though I had been through an emotional storm, I felt an unexpected peace.”

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Day 3 – Aftermath: “Waking up (if you can call it waking I hardly slept, maybe drifted in and out of visions), I was physically shaky. The nurse helped me to the bathroom. I looked in the mirror and I almost didn’t recognize myself my eyes looked softer, like a decade of fear had left them. It sounds dramatic, but it was real. Over breakfast, I realized I was hungry a simple joy I hadn’t had in years due to constant anxiety nausea. I ate fruit and eggs, and they tasted vibrant. In group therapy later that day, I found myself sharing more openly than I ever have. I talked about the moment I forgave myself. To my surprise, I wasn’t choked by anxiety as I spoke I was sad, I cried, but it felt clean, if that makes sense, not overwhelming. Listening to others, I heard echoes of my own journey. One woman said she met her childhood self during her ibogaine trip and hugged that little girl, promising to protect her now we all had tears hearing that. We started to laugh together too, marveling at what we’d just undergone. Medically, they did another ECG on me ‘all good’ they said. Honestly, the PTSD symptoms that had defined me were just…not there. My hyper-startle reflex (I used to jump at every loud sound) was noticeably subdued when a door closed loudly and I barely flinched. That evening, sitting by the pool watching the stars (something I hadn’t done in years because nights used to be when my demons came), I felt safe. I could imagine a future for the first time in so long.”

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Day 4 – New Insights: “I decided to take the optional TA booster because my gut said I wasn’t completely done. A part of me still held sorrow for all the friends I lost and the innocence lost in war. The TA journey was much milder, but still meaningful. I didn’t have intense visions this time; instead, I had a profound internal dialogue. It was as if I was communing with the spirit of the iboga plant – I know that might sound strange. I felt a warmth and the sense that everything that happened in my life was part of a story that made me who I am, and that I am exactly who I need to be now. Hard to explain, but I came out with a feeling of self-acceptance that I never had before. In the afternoon, I skipped down to the beach (actually skipped like a kid, which made the staff chuckle). I realized I felt joy a simple joy of being alive something I thought was lost forever. That day, I wrote a letter to my late friend (with the therapist’s suggestion) telling him about the life I hoped to live in his honor. I also did the ice-bath challenge with a couple of other guys from the group we cheered each other on in the cold water; it was invigorating and symbolic, like a baptism into new life. Physically, I noted my chronic back pain (from an old injury) was hardly noticeable likely because tension was released. The night of Day 4, I slept a solid 7 hours with no nightmares at all. It felt like my nervous system finally switched off high alert.”

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Day 5 – The “God” Molecule: “By now I was a believer in this process, so I was both nervous and excited for the 5-MeO-DMT session they offered. They called it an emotional/spiritual integration. I had heard it’s intense but very short. When it was my turn, I followed the instructions, inhaling the vapor deeply and lying back. What happened next… words will fail, but I’ll try: I dissolved. I mean that sense of ‘me’, the ex-soldier with all his baggage, completely disappeared. I felt like a drop of water merging into an ocean of pure love. I saw or became a blinding white light. I know I cried, but it was different than before, like tears of joy mixed with awe. In that state, it was as if I encountered the very essence of existence and it was good. I remember a powerful feeling that the universe has forgiven me and I should forgive myself a final release of any lingering guilt or unworthiness. When I came back to my body, I was laughing and crying, and I hugged the facilitator and said ‘thank you, thank you’ probably a dozen times. I felt such gratitude for life. Honestly, after ibogaine healed the wounds, 5-MeO filled me with light. Later that day, I felt so emotionally full like my heart was overflowing. We had a group meditation where I just sat in gratitude. I could sense that others were also glowing from their experiences. One of the other vets in our group, who had been pretty quiet, suddenly opened up after 5-MeO and talked about how he felt God’s presence and a sense of purpose to help others. We were all moved. That night at dinner, we actually played music and danced a bit just spontaneous fun. I couldn’t believe a few days ago I was in the depths of despair, and now I was truly happyand social.”

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Day 6 – Looking Forward: “The last full day was about making sure we don’t lose what we gained. In therapy, we made plans. I committed to a daily morning meditation (they had taught us a simple routine) and to continue therapy with a specialist back home that MindScape referred me to. We practiced some real-life scenarios; I talked about returning to my family. I’d been emotionally distant for years my wife told me before I left for this retreat that she felt like she didn’t know me anymore. Now I felt ready to reconnect. I rehearsed, with the therapist, how I might share my experience with her and apologize for the ways I’d been shut down. It felt hopeful. We also addressed a fear I had: what if the symptoms come back? The team normalized that I might have ups and downs, but I had tools now and a support plan. That was reassuring. In the afternoon, we had a beautiful closing ceremony. They gave each of us a certificate not just a paper, but they went around and spoke about each person’s journey. When it came to me, they said I had shown immense courage facing my past and that they saw me transform into someone radiating peace. I will admit, I teared up. We each shared a final thought. I said something like, ‘I came here carrying death, and I leave here carrying life. I feel like I have a future again.’ We all embraced. It’s amazing how close you can get to strangers in one week when you go through something like this together. That night, a few of us sat outside under the stars (Cozumel’s sky is so clear). We talked for hours not about trauma, but about our dreams and what we want to do now. It was like being young again, when you feel the world has possibilities. I went to bed thinking, ‘Tomorrow I go home. I can’t wait to hug my wife and actually be present with my family.’

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Day 7 – Departure: “In the morning, I did yoga by the ocean never thought I’d be a yoga person, but here we are! I felt my body, it was mine again, not just a vessel of pain. During my final check-out, Dr. Calderon showed me my before-and-after scores. My PTSD checklist was 17 on Day 6, down from 59 at intake. Objectively that’s a huge drop, but subjectively I didn’t need a number to tell me I knew I was healed in my heart. We discussed continuing NAD+ boosters perhaps in the States and keeping up with healthy nutrition. The psychologist scheduled weekly calls with me for the next month. They really didn’t just cut us loose; I felt they genuinely cared about what happens when we go back. Saying goodbye was emotional these people saw me at my worst and helped me reclaim my life. I promised to update them in a few weeks. On the journey home, I was strangely not triggered by things that would normally spike my anxiety (airports used to be hard for me). I found myself smiling at strangers. When I finally arrived and saw my wife at the airport, I hugged her tightly. She looked into my eyes and said, ‘You look different… lighter.’ I told her, ‘I am different. I’m okay now. It’s really me.’ On the drive home, I noticed the world outside – the trees, the sky – everything looked more vibrant. I felt alive, present, free. It’s as if the war inside my head has finally ended. I know integration is ongoing and life will still have challenges, but I have no doubt now that I have healed at the core. MindScape helped me do in one week what I couldn’t in ten years. It gave me back my future.”

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John’s story encapsulates many common threads reported by participants: initial skepticism and fear, the arduous but cathartic ibogaine journey confronting trauma, the near-immediate relief of long-entrenched symptoms, the deep introspective insights and emotional breakthroughs, the spiritual epiphany with 5-MeO-DMT, and the restoration of hope and connection by week’s end. While each person’s subjective experience varies, the overarching narrative of “from darkness to light” holds true for the majority in this cohort. Many have echoed John’s sentiment that one week at MindScape accomplished more for them than years of traditional therapy a testament to the potential of psychedelic-assisted trauma treatment when delivered responsibly.

 

Qualitative feedback from other participants further supports this. For instance, a 28-year-old woman with CPTSD from childhood abuse described her ibogaine experience as “finally confronting the shadows with the wisdom of an adult, and emerging feeling whole for the first time”. A 45-year-old man who suffered a near-death accident said, “The moment I faced my fear of dying during the session, I actually started living again.” Many noted that the group camaraderie and holistic care (yoga, nature, etc.) made them feel human and joyful, not just patients with a diagnosis. By integrating these personal stories with the hard data, we see both the subjective healing journey and the objective outcomes align strongly.