Quick Answer
What is the MindScape onsite taper protocol?
Reviewed by Dr. Arellano, M.D. — May 2026
SSRIs
Selective serotonin reuptake inhibitors. Hyperbolic taper with iboga TA bridge across the steepest receptor-occupancy drops.
Zoloft
Sertraline · 10–21 days onsite, drug-dependent and dose-dependent
Onsite sertraline (Zoloft) taper bridged with sub-psychoactive iboga total alkaloid under continuous cardiac telemetry.
Lexapro
Escitalopram · 10–18 days onsite
Onsite escitalopram (Lexapro) taper bridged with sub-psychoactive iboga total alkaloid — eliminates brain zaps, dizziness, and emotional rebound.
Prozac
Fluoxetine · 14–21 days onsite (driven by metabolite clearance, not parent drug)
Onsite fluoxetine (Prozac) taper using its long-half-life metabolite as a built-in bridge, augmented by full-spectrum iboga TA.
Paxil
Paroxetine · 14–28 days onsite (longest of the SSRI class)
Onsite paroxetine (Paxil) taper — the SSRI most associated with severe discontinuation syndrome — bridged with full-spectrum iboga TA.
SNRIs
Serotonin-norepinephrine reuptake inhibitors. Both serotonergic and noradrenergic withdrawal — broader TA receptor coverage.
Effexor
Venlafaxine · 14–28 days onsite
Onsite venlafaxine (Effexor) taper — the SNRI with the most severe withdrawal — bridged with full-spectrum iboga TA.
Cymbalta
Duloxetine · 14–24 days onsite
Onsite duloxetine (Cymbalta) taper bridged with iboga TA — capsule-bead micro-tapering under continuous telemetry.
Benzodiazepines
GABA-A modulators with seizure risk on abrupt cessation. Cross-titration to long-half-life benzodiazepine, then Ashton-method hyperbolic taper with TA bridge.
Xanax
Alprazolam · 21–60 days onsite (longest of any class — driven by seizure-safety floor)
Onsite alprazolam (Xanax) taper — the most withdrawal-severe benzodiazepine — under continuous cardiac telemetry with iboga TA bridging.
Klonopin
Clonazepam · 21–45 days onsite
Onsite clonazepam (Klonopin) taper — long half-life makes it the preferred cross-titration target — bridged with full-spectrum iboga TA.
Ativan
Lorazepam · 21–45 days onsite
Onsite lorazepam (Ativan) taper — cross-titration to diazepam first, then hyperbolic Ashton-method taper with iboga TA bridge.
Z-Drugs (Sleep Medications)
GABA-A α1-subunit-selective hypnotics. Cross-titration to diazepam followed by hyperbolic taper with TA bridge and sleep-architecture restoration.
Important Hedge
These pages are educational, not personal medical advice.
Drug-specific taper guides describe the MindScape onsite protocol in general terms. Day-counts and dose ranges are illustrative — every onsite taper is individualized after baseline cardiac, hepatic, electrolyte, and pharmacogenomic workup. Do not modify or discontinue prescribed medications without supervised medical support. Abrupt cessation of benzodiazepines or short-acting opioids can be dangerous.
Find Out if You're a Candidate
Start with a free, confidential medical pre-screening — reviewed personally by our clinical team, with no obligation. Every medication discontinuation case is screened individually.
Start Free Medical Pre-Screening →