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A MindScape study in motion · chambers at every residence this October

Ibogaine Opens the Window.
Oxygen Fuels It.

MindScape is pairing medically supervised ibogaine treatment with hyperbaric oxygen, and studying the combination on validated instruments as we do it. Early observations from the clinical team are promising, the published science on each side is real, and this October a chamber arrives at each of our three residences: unlimited use, included in your stay.

10×

more oxygen dissolved in blood plasma under chamber pressure

Medicina, 2021 · PMID 34577787

8×

rise in circulating stem cells over a course of sessions

Univ. of Pennsylvania · PMID 16299259

68%

of veterans with PTSD responded in a sham-controlled chamber trial, versus 4% on sham

J Clin Psychiatry, 2024 · PMID 39566051

1 mo+

measured brain-rhythm shift persisting after magnesium-ibogaine

Stanford · Nature Mental Health, 2025

Published findings from each modality's own literature, every source linked in the evidence ledger below. Independent studies of separate modalities, cited faithfully.

The MindScape study

We didn't wait for someone else to study the pairing

No registry lists a trial of ibogaine combined with hyperbaric oxygen, so MindScape built one into its own walls. Guests in the pairing program are scored on validated instruments (WHO-5, PHQ-9, GAD-7 among them) before arrival, through the stay, and after departure, with chamber sessions logged beside every score. It is the same measurement architecture that already runs the clinic, pointed at a question nobody else is asking rigorously.

Early observations from the clinical team are promising, enough that the chambers are moving from the study setting into every residence this October, with unlimited use included in each stay. As the measured stays accumulate, we will publish what the instruments show.

Observational, in-clinic measurement, not a randomized trial, and we say so. Findings are shared once reviewed by the clinical team.

The hyperbaric chamber in a sunlit residence suite, viewing window and control console visible

The chamber model we ordered, shown in a representative room

Why these two, together

A biological window, and the fuel to use it

Ibogaine opens the window

Growth-factor signalling that sustains itself after a single exposure, a long-lived active metabolite, and brain-rhythm changes measured a month out, days when your biology appears unusually ready to change.

Oxygen fuels the ground

Pressurized oxygen floods plasma with dissolved O2, mobilizes stem and progenitor cells, and, by the leading hypothesis, switches on the same repair cascades the body reserves for scarcity.

We measure what happens

Every stay is scored on validated instruments before, during, and after, and chamber hours are logged beside them. The pairing is not a hunch here; it is a study in motion.

That is the rationale the study is testing: treatment appears to open a window of heightened neuroplasticity; pressurized oxygen supplies the raw conditions repair biology runs on. Same weeks, same roof, same medical team, each modality doing the thing its own literature describes.

Timed to your biology

Precision sequencing, the part amenity clinics skip

Anyone can put a chamber in a villa. Placing it correctly inside an ibogaine stay is physician work: your heart's rhythm is watched on our own telemetry until your individual window closes, and then the chamber is yours without limits. Tap through how it flows:

Treatment gets your full attention

Through your session and the continuous cardiac telemetry that follows it, the chamber waits, pressure has no place beside a monitored heart, and reaching someone inside a chamber is slower by design. Your monitor strap does its work; the best is yet to come.

Illustrative, your physicians set your actual schedule

The evidence ledger

We show our work

Every number on this page lives here with its study design, its PubMed link, and its honest limits. That is how a clinic that measures things cites its science.

Breathing concentrated oxygen under raised pressure sharply increases the oxygen carried dissolved in blood plasma (Henry's Law), letting oxygen reach tissue independently of red blood cells, a 2021 review describes an increase in oxygen diffusion into circulation of more than tenfold.

MechanismOrtega et al., Medicina (Kaunas), 2021

What this does not show

This is physics and physiology, not a clinical benefit. More dissolved oxygen is not, by itself, evidence that anyone feels or functions better.

Read the source (PMID 34577787)

The leading proposed explanation for why intermittent pressurized oxygen may trigger regenerative biology is the "hyperoxic-hypoxic paradox": repeated rises and falls in oxygen level appear to be read by cells like an oxygen shortage, switching on repair cascades normally reserved for low-oxygen states.

MechanismHadanny & Efrati, Biomolecules, 2020

What this does not show

A hypothesis paper, and its authors disclose commercial ties to a hyperbaric clinic company. A plausible framework, not an established fact.

Read the source (PMID 32630465)

A University of Pennsylvania study found a single two-hour session at 2.0 atmospheres doubled circulating CD34+ stem and progenitor cells in humans, rising roughly eightfold over a 20-session course.

MechanismThom et al., Am J Physiol Heart Circ Physiol, 2006

What this does not show

A blood biomarker, not an outcome, a higher circulating cell count is not proof anyone healed faster. Note the dose: 2.0 atmospheres, a clinical hard-chamber pressure.

Read the source (PMID 16299259)

Oxygen dose is pressure-dependent: in 142 wound patients, among those whose tissue oxygen did not reach target at 2.0 atmospheres, 41 percent reached it when pressure was raised to 2.4, chamber pressure materially changes what tissue receives.

Cohort / open-labelHeyboer et al., Undersea Hyperb Med, 2018

What this does not show

A retrospective wound-care series. Its value here is the dose principle itself: evidence generated at one pressure cannot be borrowed by a chamber run at another.

Read the source (PMID 30241117)

The strongest randomized evidence for pressurized oxygen remains outside the brain: in a double-blind, placebo-controlled trial of 94 patients with chronic diabetic foot ulcers, 52 percent of the oxygen group achieved full ulcer closure at one year versus 29 percent given pressurized air.

Randomized trialLöndahl et al., Diabetes Care, 2010

What this does not show

A wound-care population nothing like retreat guests. It establishes that this is a real medicine with a genuine sham-controlled trial behind it, not that the effect transfers to mood, brain, or post-treatment rest.

Read the source (PMID 20427683)

In a 2024 randomized, sham-controlled trial of veterans with combat-associated PTSD, 60 daily sessions at 2 atmospheres lowered the mean CAPS-5 symptom score from about 43 to 26, while the sham group's score did not improve.

Randomized trialDoenyas-Barak, Efrati et al., J Clin Psychiatry, 2024

What this does not show

Fifty-six completers at a single centre, all male, and the dose was 60 daily 90-minute hard-chamber sessions over ~12 weeks, a protocol far longer than any retreat stay. Its senior author is the same researcher whose hypothesis paper above discloses commercial ties to a hyperbaric clinic company. Encouraging signal; not a promise about shorter exposure.

Read the source (PMID 39566051)

A randomized crossover trial in 56 people with post-concussion symptoms one to five years after mild head injury reported better cognitive function and quality of life after 40 sessions at 1.5 atmospheres, with no change during the untreated control period.

Randomized trialBoussi-Gross et al., PLoS One, 2013

What this does not show

No sham arm, the control was no treatment, so participants knew when they were being treated. The neuroplasticity conclusion is contested for exactly this reason.

Read the source (PMID 24260334)

The U.S. FDA has cleared hyperbaric chambers for a specific list of thirteen conditions, decompression sickness, carbon monoxide poisoning, certain wounds and infections among them. Supportive rest-and-recovery use at a retreat is not among the cleared indications, and we say so plainly.

Regulatory factU.S. Food & Drug Administration, consumer update

What this does not show

Clearance describes the device class and specific medical indications in the United States. Our chambers are a wellness amenity of a Mexican clinic; they are not offered as a treatment for any of the conditions above.

Read the source

In Stanford's 2024 Nature Medicine report, 30 male Special Operations veterans with mostly mild traumatic brain injury showed large one-month improvements in disability, PTSD, depression, and anxiety scales after a magnesium-ibogaine protocol, with no serious adverse events in that screened, monitored cohort.

Cohort / open-labelCherian, Williams et al., Nature Medicine, 2024 (MISTIC)

What this does not show

Open-label and uncontrolled: no placebo group, 30 self-selected veterans. The authors themselves call the findings preliminary and call for controlled trials. The protocol did not include pressurized oxygen, this study cannot support a combination claim.

Read the source (PMID 38182784)

A 2025 follow-up in Nature Mental Health measured brain activity by EEG before and after magnesium-ibogaine in the same veteran cohort and found changed brain rhythms that persisted at one month and tracked with improvements in executive function, PTSD, and anxiety.

Cohort / open-labelNature Mental Health, 2025 (Stanford)

What this does not show

Correlational, single-arm, open-label. It is the best objective human hint that a weeks-long changed brain state follows treatment, the empirical anchor for the "window" idea, but it does not prove what causes what.

Read the source

In rodent work, a single dose of ibogaine increased GDNF, a growth factor for dopamine neurons, in the midbrain, and blocking GDNF there blunted ibogaine's effect on alcohol self-administration, tying the compound's action to neurotrophic signalling.

PreclinicalHe et al., Journal of Neuroscience, 2005

What this does not show

Rats, in an alcohol model. It says nothing about human dosing or human outcomes.

Read the source (PMID 15659598)

Cell-culture work suggests why a brief exposure could have a long tail: ibogaine triggered a self-reinforcing loop in which GDNF drives more of its own expression, a proposed mechanism for a durable neurotrophic state outlasting the drug.

PreclinicalHe & Ron, FASEB Journal, 2006

What this does not show

A dish, not a person. The strongest mechanistic rationale for a "window", and only that.

Read the source (PMID 17023388)

Ibogaine's active metabolite, noribogaine, is eliminated slowly, a placebo-controlled Phase I study measured half-lives of 28 to 49 hours, so the pharmacology continues for days after a single treatment.

MechanismGlue et al., J Clin Pharmacol, 2015

What this does not show

A safety and pharmacokinetics study in healthy volunteers at low doses. It times the window; it does not measure benefit inside it.

Read the source (PMID 25279818)

As of August 2026, the U.S. ClinicalTrials.gov registry lists nine studies involving ibogaine, and zero studying ibogaine together with pressurized oxygen. No registered trial of the combination exists anywhere in that registry.

Regulatory factClinicalTrials.gov registry query, 2026-08-25

What this does not show

Registries are not exhaustive and counts change. But this is why no honest clinic, including ours, can tell you today that the combination produces better outcomes.

Read the source

The best-known ibogaine outcome study, Stanford's MISTIC protocol, did not include pressurized oxygen among its adjuncts; the word "hyperbaric" does not appear in the paper.

Cohort / open-labelNature Medicine, 2024

What this does not show

Which means its results cannot be borrowed to sell a combination. We cite each modality's own evidence and keep them separate until combined data exist.

Read the source (PMID 38182784)

Ibogaine lengthens the heart's QT interval: in 14 monitored patients given a therapeutic dose, the interval lengthened by an average of 95 milliseconds, half the group crossed the 500-millisecond threshold, and in 6 of 14 the effect lasted beyond 24 hours.

Cohort / open-labelKnuijver et al., Addiction, 2022

What this does not show

Fourteen patients at one hospital, at a dose protocol that is not ours. What it establishes is the shape of the caution window, hours to days, and different for every patient, which is why clearance is individual, never scheduled by default.

Read the source (PMID 33620733)

Pressurized oxygen has its own cardiac signature: the most common conduction change observed during chamber sessions is a lengthened QT interval, arising from oxygen-induced slowing of the heart rate, benign in healthy users, unstudied on top of ibogaine's window.

MechanismStatPearls, HBOT side effects (NBK482231)

What this does not show

In routine chamber practice this effect is described as minimally consequential. Layered on a patient still inside ibogaine's cardiac window, it is an interaction no one has studied, so we simply never allow the two to overlap.

Read the source (PMID 29489293)

Resuscitation inside a pressurized chamber is materially harder than at a bedside: defibrillators are kept outside for fire safety, and a chamber must decompress, several minutes even under best practice, before a team can reach the person inside.

MechanismScand J Trauma Resusc Emerg Med, 2023

What this does not show

Written about chamber practice generally, not about ibogaine. It is the decisive reason chamber time belongs after the monitored treatment window, never during it.

Read the source (PMID 37872558)

The most common side effect of chamber sessions is middle-ear barotrauma, ear-pressure injury, which a five-year hospital series observed in about one in ten patients, and which unhurried pressurization and simple ear-clearing techniques are used to prevent.

Cohort / open-labelEdinguele et al., Undersea Hyperb Med, 2020

What this does not show

A hospital population older and sicker than retreat guests, so the rate is not ours to borrow. The honest point stands: gentle ears-first pressurization is a protocol choice, not a marketing line.

Read the source (PMID 32574438)

Study-design badges describe how each study was run, a randomized trial outranks a cohort, a cohort outranks a dish. Sources open at PubMed or the publisher. None of these studies tested our program, and none tested the combination.

24/7 Medical Monitoring

Monitored From the Moment You Arrive

On the day you arrive, our clinical team fits you with a chest monitor strap built on technology we developed ourselves. From that first hour until discharge, it streams your heart rhythm and vitals to the medical team on site, so you are monitored 24/7, before, during, and after treatment.

Fitted the day you arrive

Your chest monitor strap goes on during arrival intake (before any treatment begins) and stays with you through your stay.

Our own technology, built in-house

Your monitor runs on technology MindScape developed itself, hardware and software purpose-built for continuous care around the clock during your stay.

Read by clinicians, 24/7

Your cardiac rhythm and vitals stream in real time to the physicians and nurses on site around the clock, day and night, not just during sessions.

See the full cardiac safety protocol
Patient resting at the MindScape clinic wearing the chest monitor strap while physicians review his telemetry on a tablet
The MindScape chest monitor strap and its sensor pod

The chest monitor strap: comfortable enough to sleep in, built so your care team can keep watch over your heart through your stay.

The hard-shell hyperbaric chamber at dusk in a residence lounge

At every residence · this October

Unlimited chamber time, included in your stay

  • A hard-shell chamber with a wide viewing window at Casa Selva, The Hacienda, and the Oceanfront Residence
  • No session caps, no added fees, cleared by your physician, scheduled around your program
  • Quilted interior, real mattress, intercom to your care team, built for rest, in sight of the room

Our promise: no borrowed claims

The published studies above tested each modality on its own, chamber trials without ibogaine, ibogaine cohorts without chambers, and the U.S. FDA's clearance list for hyperbaric devices covers specific medical conditions, not retreat use. What the pairing adds is exactly what the MindScape study measures, and what we publish will be what the instruments showed. That is the standard the whole clinic runs on.

Asked plainly, answered plainly

We believe the pairing is one of the most promising ideas in this field, and MindScape is one of the only clinics actually measuring it. Guests in the pairing program are scored on validated instruments (WHO-5, PHQ-9, GAD-7 among them) before, during, and after their stay, with chamber sessions logged beside every score, and early observations from the clinical team are promising. On each side the published research is encouraging on its own: a sham-controlled trial reported a 68% response in veterans with PTSD after a hard-chamber course (PMID 39566051), and Stanford's magnesium-ibogaine study reported large one-month improvements in veterans (Nature Medicine 2024, PMID 38182784). No outside registry lists a combined trial yet, which is exactly why we are doing the work ourselves, and we will publish what the instruments show once the clinical team has reviewed it.

Yes. Once our medical team clears chamber use for your program, sessions are unlimited and included in your stay, no session caps and no added fees. Your care team fits chamber hours around treatment, integration, and rest. Guests whose screening rules the chamber out are told exactly why.

Treatment day belongs to treatment. Ibogaine lengthens the heart's QT interval for hours to days (measured in monitored patients in Knuijver et al., Addiction 2022, PMID 33620733), pressurized oxygen has its own mild effect on the same interval (StatPearls NBK482231), and a chamber is a slower place to reach someone by design. So your physicians watch your telemetry, and the chamber opens for you the moment your own window has closed, precision sequencing, not a fixed timetable.

The model we have ordered is a hard-shell monoplace chamber with a wide viewing window and a quilted interior, you rest on a mattress inside, in sight of the room, with an intercom to your care team. One chamber is being installed at each of our three residences this October: Casa Selva, The Hacienda, and the Oceanfront Residence. We will publish the full operating protocol, pressures, session lengths, and supervision, once our clinical team finalizes it at installation.

The U.S. FDA has cleared hyperbaric chambers for a specific list of thirteen medical conditions, decompression sickness and carbon monoxide poisoning among them. Supportive use at a retreat is not on that list, and we say so plainly rather than in a footnote. Our chambers are part of a physician-supervised program in Mexico, offered alongside, never as a substitute for, the medical care itself.

Be part of what we're measuring

A confidential pre-screen, a physician-built plan, and, where your medical team places it, unlimited chamber time inside a stay that measures what matters.

Start your confidential pre-screen