MindScape Medical AI — Ibogaine Research Intelligence
Clinical Intelligence Platform

MindScape Medical AI

The world's largest ibogaine treatment dataset — 947 patients, 284,000+ clinical data points — powering AI-driven protocol optimization, safety monitoring, and outcome prediction.

947+
Patients Treated
284K+
Data Points
147
Studies Analyzed
0.00%
Mortality Rate
DA
Medically reviewed by Dr Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 900 patients treated.
Last reviewed: March 2026
Clinical Outcomes

Real Patient Data, Real Results

Every number below comes from validated clinical assessments administered to real patients. No estimates, no projections — just data.

Opioid Use Disorder

87.4%
Success Rate
78.2%
COWS Reduction
28.46.2(COWS score)
n = 412 patients

PTSD / C-PTSD

82.7%
Success Rate
62.3%
PCL-5 Reduction
54.220.4(PCL-5 score)
n = 134 patients

Depression

79.6%
Success Rate
58.1%
PHQ-9 Reduction
18.67.8(PHQ-9 score)
n = 98 patients

Alcohol Use Disorder

74.3%
Success Rate
71.5%
AUDIT Reduction
n = 67 patients

Heroin Addiction

84.1%
Success Rate
75.8%
COWS Reduction
n = 189 patients

Methadone Dependency

81.2%
Success Rate
73.9%
COWS Reduction
n = 47 patients
Pharmacology

How Ibogaine Resets the Brain

Ibogaine acts on six distinct neural pathways simultaneously — no other known substance has this breadth of action.

A
NMDA Receptor
Antagonist
Interrupts addiction memory circuits
A
Kappa Opioid
Agonist
Modulates mood and reduces craving
P
Mu Opioid
Partial Agonist
Attenuates withdrawal symptoms
A
Sigma-2
Agonist
Neuroprotection & neuroplasticity
I
Serotonin Transporter
Inhibitor
Antidepressant properties
U
GDNF Expression
Upregulation
Dopamine neuron restoration
Active Metabolite: Noribogaine
Ibogaine is converted via CYP2D6 into noribogaine, which has a half-life of 28–49 hours. This long-acting metabolite sustains the anti-addictive effect for weeks, providing a critical window for neural rewiring and behavioral change.
28-49h
Half-life
3-6mo
Craving Reduction
Safety Profile

Cardiac Monitoring: Zero Mortality

QTc prolongation is the primary cardiac risk of ibogaine. Our AI monitors every heartbeat in real time.

28,456
Monitoring Entries
412ms
Avg Baseline QTc
448ms
Avg Peak QTc
497ms
Max QTc Recorded
0.38%
QTc >470ms Rate
100%
Resolve to Baseline
Rhythm Distribution (n=28,456)
87.6%
Normal Sinus
9.5%
Sinus Brady
2.0%
Sinus Tachy
0.6%
PVCs
0.2%
AFib
AI-Powered Intelligence

What Our AI Discovers

No other ibogaine clinic has 947+ structured patient outcomes feeding an AI analysis engine. Here's what it's found.

H

QTc Trend Analysis

Real-time cardiac monitoring with automated alert thresholds. Predicts QTc trajectory from baseline vitals with 94% accuracy.

D

Dose Optimization

Weight-adjusted dosing curves personalized per patient profile. Our AI identified the 0.20–0.22 mg/kg sweet spot delivering 81–86% COWS reduction.

R

Risk Scoring

Predictive adverse event risk scoring from baseline assessments. Flags high-risk patients before treatment begins.

O

Outcome Forecasting

Projects treatment trajectory from intake data. Helps set realistic expectations and customize protocol intensity.

P

Protocol Refinement

Continuous multi-scale outcome aggregation discovers what works. Found that day 3-5 boosters improve 30-day retention by 23%.

S

Research Synthesis

Scans 147+ published studies cross-referenced against our clinical dataset. Identifies gaps between literature and real-world outcomes.

Breakthrough Insights

5 Findings That Changed Our Protocols

1

Weight-adjusted dosing outperforms fixed dosing by 23%

mg/kg calculations produce more consistent COWS reductions across all weight classes.

2

HCL formulation: 8.7% better outcomes, 56% less emesis than TA

Ibogaine HCL offers more predictable pharmacokinetics and fewer gastrointestinal side effects.

3

QTc delta from baseline predicts cardiac risk 2.4x better than absolute QTc

Individual change matters more than static thresholds — reshaping how we think about cardiac safety.

4

Dual diagnosis (OUD + PTSD) patients show 12% higher improvement

Treating both conditions simultaneously yields significantly better results than sequential approaches.

5

Day 3-5 booster doses improve 30-day retention by 23%

Small supplemental doses during the integration window extend the anti-craving effect through the critical first month.

HCL vs TA: Formulation Comparison

Head-to-head data from 1,203 treatment sessions

MetricIbogaine HCLTotal Alkaloid (TA)
Doses Administered847356
COWS Reduction81.3%74.8%
Emesis Rate12.4%28.1%
Re-dose Rate8.7%15.3%
Avg Resolution Time14.2 hours18.6 hours

Data-Driven Treatment Starts Here

947 patients have generated the evidence. Our AI has found the patterns. Now it's your turn to benefit from the most data-informed ibogaine protocol on earth.

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