Iboga Alkaloid Encyclopedia · Minor Alkaloid
Ibogamine
Cardiac-sparing minor indole alkaloid in iboga TA — present at meaningful share, contributes to TA's broader receptor footprint.
Molecular formula
C₁₉H₂₄N₂
Molecular weight
280.41 g/mol
CAS registry
481-86-7
TA share (approx.)
≈ 5–10% of TA mass
IUPAC / systematic
Ibogamine
Profile
Ibogamine is a structurally close iboga-type indole alkaloid lacking the methoxy group of ibogaine. In animal and in-vitro studies it shows behaviorally relevant central activity at doses comparable to ibogaine but with a less pronounced hERG signal in published in-vitro screens.
Ibogamine is one of the alkaloids that distinguishes full-spectrum TA from purified ibogaine HCl. It is present at meaningful share in iboga root bark TA and contributes to the broader receptor footprint that the taper protocol is designed to engage.
Receptor & Target Profile
- Mu and kappa opioid receptors: low-to-moderate affinity ligand activity reported.
- Sigma receptors: binding reported.
- hERG / QT: less pronounced in-vitro signal than ibogaine in published screens.
Role at MindScape
Contributes to the TA bridge's broader receptor coverage during taper at sub-psychoactive doses; not used as a standalone agent.
Citations
- Alper KR. (2001). The Alkaloids: Chemistry and Biology, 56, 1-38.
- Glick SD, et al. (2000). Brain Research, 877(1), 200-202.
Citation list is illustrative. Where peer-reviewed data is thin or absent, MindScape's pharmacology summary draws on textbook references (Alper 2001 — The Alkaloids: Chemistry and Biology, vol. 56) and is hedged accordingly.
Related alkaloids
Ibogaine
The primary psychoactive indole alkaloid in Tabernanthe iboga; the molecule used at flood-dose for opioid-use-disorder reset.
Tabernanthine
Mild psychoactive minor indole alkaloid in iboga TA; isomeric cousin of ibogaine.
Voacangine
Synthetic precursor to ibogaine; 12-methoxy ibogaine analog with its own anti-addictive profile.