Lisinopril
Zestril, Prinivil
Ibogaine and Warfarin
Also known as: Coumadin, Jantoven
Vitamin K antagonist with a NARROW therapeutic index and CYP2C9 metabolism — INR moves with diet, vomiting, dehydration and interacting drugs, all of which occur around treatment.
Severity
Moderate caution
Mechanism
Other clinical interaction
Protocol Status
Continues — any change is the prescribing physician's decision, made before arrival
Restart Delay
Physician discretion
What "Moderate caution" Means
Use with caution. Often requires a brief hold, dose reduction, or enhanced monitoring rather than full discontinuation.
Clinical Action
What our medical team does for patients on Warfarin.
Do NOT stop or hold on our initiative. Confirm INR monitoring with the prescribing physician before arrival; the fast and any vomiting can shift it.
Where the Washout Happens
Continues — any change is the prescribing physician's decision, made before arrival
This medication is not stopped on our initiative and there is no washout interval we can set: what governs it is a clinical judgement that belongs to the prescribing physician, not a waiting period we can count. It is documented, flagged to the medical team, and the plan is confirmed with the prescriber BEFORE any invasive procedure or IV placement. Stopping an anticoagulant or antiplatelet without that conversation carries its own risk, which is why the default here is to continue and confirm rather than to hold.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Warfarin interacts with ibogaine: other clinical interaction.
This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Same Mechanism
Other medications that interact via other clinical interaction.
Same Severity Tier
Other moderate caution medications (different mechanism).
QT-interval prolongation
Ondansetron
Zofran
QT-interval prolongation
Azithromycin
Zithromax, Z-Pack
Cardiac conduction (bradycardia / AV node)
Metoprolol
Lopressor, Toprol
Cardiac conduction (bradycardia / AV node)
Atenolol
Tenormin
Cardiac conduction (bradycardia / AV node)
Propranolol
Inderal
Cardiac conduction (bradycardia / AV node)
Carvedilol
Coreg
Common Questions
Warfarin and ibogaine treatment.
Can I take ibogaine if I am on Warfarin?
Moderate caution. Vitamin K antagonist with a NARROW therapeutic index and CYP2C9 metabolism — INR moves with diet, vomiting, dehydration and interacting drugs, all of which occur around treatment. Do NOT stop or hold on our initiative. Confirm INR monitoring with the prescribing physician before arrival; the fast and any vomiting can shift it.
How long do I need to be off Warfarin before ibogaine treatment?
Continues — any change is the prescribing physician's decision, made before arrival. This medication is not stopped on our initiative and there is no washout interval we can set: what governs it is a clinical judgement that belongs to the prescribing physician, not a waiting period we can count. It is documented, flagged to the medical team, and the plan is confirmed with the prescriber BEFORE any invasive procedure or IV placement. Stopping an anticoagulant or antiplatelet without that conversation carries its own risk, which is why the default here is to continue and confirm rather than to hold.
What is the mechanism of the interaction?
Other clinical interaction. This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Warfarin — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
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DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 1,000 patients treated.
Last reviewed: May 2026 · See full medical team