Enalapril
Vasotec
Ibogaine and Lisinopril
Also known as: Zestril, Prinivil
May enhance ibogaine-related hypotension.
Severity
Minor — monitor
Mechanism
Other clinical interaction
Protocol Status
Pre-arrival washout (under your prescribing physician)
Restart Delay
Physician discretion
What "Minor — monitor" Means
Generally safe. May require a hold on dosing day or post-treatment monitoring depending on individual response.
Clinical Action
What our medical team does for patients on Lisinopril.
Hold on treatment day if BP tends low. Resume next day.
Where the Washout Happens
Pre-arrival washout (under your prescribing physician)
Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose.
Pre-Treatment Washout Window
Hold on dosing day; physician-directed timing.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Lisinopril interacts with ibogaine: other clinical interaction.
This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Same Mechanism
Other medications that interact via other clinical interaction.
Same Severity Tier
Other minor — monitor medications (different mechanism).
Common Questions
Lisinopril and ibogaine treatment.
Can I take ibogaine if I am on Lisinopril?
Minor — monitor. May enhance ibogaine-related hypotension. Hold on treatment day if BP tends low. Resume next day.
How long do I need to be off Lisinopril before ibogaine treatment?
Pre-arrival washout (under your prescribing physician). Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose. Hold on dosing day; physician-directed timing.
What is the mechanism of the interaction?
Other clinical interaction. This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Lisinopril — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
Browse all 103 medications in the A–Z directory.
DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 900 patients treated.
Last reviewed: May 2026 · See full medical team