Alprazolam
Xanax
Ibogaine and Pregabalin
Also known as: Lyrica
CNS depression. Enhances sedation.
Severity
Moderate caution
Mechanism
Central nervous system depression
Protocol Status
Pre-arrival washout (under your prescribing physician)
Restart Delay
Physician discretion
What "Moderate caution" Means
Use with caution. Often requires a brief hold, dose reduction, or enhanced monitoring rather than full discontinuation.
Clinical Action
What our medical team does for patients on Pregabalin.
Reduce dose during treatment period.
Where the Washout Happens
Pre-arrival washout (under your prescribing physician)
Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose.
Pre-Treatment Washout Window
Hold on dosing day; physician-directed timing.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Pregabalin interacts with ibogaine: central nervous system depression.
Sedatives — benzodiazepines, gabapentinoids, alcohol, sedating antihistamines, sleep aids — add to ibogaine's own sedation, ataxia, and respiratory effects. Concomitant CNS depressants are tapered before treatment and reintroduced cautiously after the active dosing window closes.
Same Mechanism
Other medications that interact via central nervous system depression.
Same Severity Tier
Other moderate caution medications (different mechanism).
QT-interval prolongation
Ondansetron
Zofran
QT-interval prolongation
Azithromycin
Zithromax, Z-Pack
Cardiac conduction (bradycardia / AV node)
Metoprolol
Lopressor, Toprol
Cardiac conduction (bradycardia / AV node)
Atenolol
Tenormin
Cardiac conduction (bradycardia / AV node)
Propranolol
Inderal
Cardiac conduction (bradycardia / AV node)
Carvedilol
Coreg
Common Questions
Pregabalin and ibogaine treatment.
Can I take ibogaine if I am on Pregabalin?
Moderate caution. CNS depression. Enhances sedation. Reduce dose during treatment period.
How long do I need to be off Pregabalin before ibogaine treatment?
Pre-arrival washout (under your prescribing physician). Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose. Hold on dosing day; physician-directed timing.
What is the mechanism of the interaction?
Central nervous system depression. Sedatives — benzodiazepines, gabapentinoids, alcohol, sedating antihistamines, sleep aids — add to ibogaine's own sedation, ataxia, and respiratory effects. Concomitant CNS depressants are tapered before treatment and reintroduced cautiously after the active dosing window closes.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Pregabalin — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
Browse all 103 medications in the A–Z directory.
DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 900 patients treated.
Last reviewed: May 2026 · See full medical team