Lisinopril
Zestril, Prinivil
Ibogaine and Vibegron
Also known as: Gemtessa
Beta-3 adrenergic agonist for overactive bladder. Minimal CYP involvement; no established ibogaine interaction.
Severity
Minor — monitor
Mechanism
Other clinical interaction
Protocol Status
Pre-arrival washout (under your prescribing physician)
Restart Delay
Physician discretion
What "Minor — monitor" Means
Generally safe. May require a hold on dosing day or post-treatment monitoring depending on individual response.
Clinical Action
What our medical team does for patients on Vibegron.
May continue during treatment. Note the sympathomimetic class if HR is being watched closely.
Where the Washout Happens
Pre-arrival washout (under your prescribing physician)
Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose.
Pre-Treatment Washout Window
May be used during treatment with monitoring.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Vibegron interacts with ibogaine: other clinical interaction.
This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Same Mechanism
Other medications that interact via other clinical interaction.
Same Severity Tier
Other minor — monitor medications (different mechanism).
Common Questions
Vibegron and ibogaine treatment.
Can I take ibogaine if I am on Vibegron?
Minor — monitor. Beta-3 adrenergic agonist for overactive bladder. Minimal CYP involvement; no established ibogaine interaction. May continue during treatment. Note the sympathomimetic class if HR is being watched closely.
How long do I need to be off Vibegron before ibogaine treatment?
Pre-arrival washout (under your prescribing physician). Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose. May be used during treatment with monitoring.
What is the mechanism of the interaction?
Other clinical interaction. This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Vibegron — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
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DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 1,000 patients treated.
Last reviewed: May 2026 · See full medical team