Phenelzine
Nardil
Ibogaine and Rasagiline
Also known as: Azilect
MAO-B inhibitor. Risk of serotonin syndrome.
Severity
Contraindicated
Mechanism
Monoamine oxidase inhibition
Protocol Status
Pre-arrival washout (under your prescribing physician)
Restart Delay
Physician discretion
What "Contraindicated" Means
Absolute prohibition without an enforced washout. Treatment cannot proceed safely until the medication has been cleared from the body for the protocol's required interval.
Clinical Action
What our medical team does for patients on Rasagiline.
Discontinue minimum 14 days before treatment.
Where the Washout Happens
Pre-arrival washout (under your prescribing physician)
Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose.
Pre-Treatment Washout Window
14 days minimum before treatment.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Rasagiline interacts with ibogaine: monoamine oxidase inhibition.
MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiline, rasagiline, moclobemide, ayahuasca) prevent breakdown of serotonin, dopamine, and norepinephrine. Combined with noribogaine's serotonergic activity, the result can be fatal serotonin syndrome and hypertensive crisis. This is an absolute contraindication with the longest enforced washout in the protocol.
Same Mechanism
Other medications that interact via monoamine oxidase inhibition.
Same Severity Tier
Other contraindicated medications (different mechanism).
Serotonergic activity (serotonin syndrome)
Fluoxetine
Prozac, Sarafem
Serotonergic activity (serotonin syndrome)
Sertraline
Zoloft
Serotonergic activity (serotonin syndrome)
Paroxetine
Paxil, Pexeva
QT-interval prolongation
Citalopram
Celexa
QT-interval prolongation
Escitalopram
Lexapro
Serotonergic activity (serotonin syndrome)
Fluvoxamine
Luvox
Common Questions
Rasagiline and ibogaine treatment.
Can I take ibogaine if I am on Rasagiline?
Contraindicated. MAO-B inhibitor. Risk of serotonin syndrome. Discontinue minimum 14 days before treatment.
How long do I need to be off Rasagiline before ibogaine treatment?
Pre-arrival washout (under your prescribing physician). Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose. 14 days minimum before treatment.
What is the mechanism of the interaction?
Monoamine oxidase inhibition. MAOIs (phenelzine, tranylcypromine, isocarboxazid, selegiline, rasagiline, moclobemide, ayahuasca) prevent breakdown of serotonin, dopamine, and norepinephrine. Combined with noribogaine's serotonergic activity, the result can be fatal serotonin syndrome and hypertensive crisis. This is an absolute contraindication with the longest enforced washout in the protocol.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Rasagiline — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
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DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 900 patients treated.
Last reviewed: May 2026 · See full medical team