Lisinopril
Zestril, Prinivil
Ibogaine and Ibuprofen
Also known as: Advil, Motrin, Nurofen
NSAID. Renal and gastric effects matter more than usual around fasting, vomiting and reduced intake; adds bleeding risk if the patient is also anticoagulated.
Severity
Minor — monitor
Mechanism
Other clinical interaction
Protocol Status
Continues — any change is the prescribing physician's decision, made before arrival
Restart Delay
Physician discretion
What "Minor — monitor" Means
Generally safe. May require a hold on dosing day or post-treatment monitoring depending on individual response.
Clinical Action
What our medical team does for patients on Ibuprofen.
Prefer to avoid around the fast and the acute phase, especially with any anticoagulant or reduced oral intake.
Where the Washout Happens
Continues — any change is the prescribing physician's decision, made before arrival
This medication is not stopped on our initiative and there is no washout interval we can set: what governs it is a clinical judgement that belongs to the prescribing physician, not a waiting period we can count. It is documented, flagged to the medical team, and the plan is confirmed with the prescriber BEFORE any invasive procedure or IV placement. Stopping an anticoagulant or antiplatelet without that conversation carries its own risk, which is why the default here is to continue and confirm rather than to hold.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Ibuprofen interacts with ibogaine: other clinical interaction.
This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Same Mechanism
Other medications that interact via other clinical interaction.
Same Severity Tier
Other minor — monitor medications (different mechanism).
Common Questions
Ibuprofen and ibogaine treatment.
Can I take ibogaine if I am on Ibuprofen?
Minor — monitor. NSAID. Renal and gastric effects matter more than usual around fasting, vomiting and reduced intake; adds bleeding risk if the patient is also anticoagulated. Prefer to avoid around the fast and the acute phase, especially with any anticoagulant or reduced oral intake.
How long do I need to be off Ibuprofen before ibogaine treatment?
Continues — any change is the prescribing physician's decision, made before arrival. This medication is not stopped on our initiative and there is no washout interval we can set: what governs it is a clinical judgement that belongs to the prescribing physician, not a waiting period we can count. It is documented, flagged to the medical team, and the plan is confirmed with the prescriber BEFORE any invasive procedure or IV placement. Stopping an anticoagulant or antiplatelet without that conversation carries its own risk, which is why the default here is to continue and confirm rather than to hold.
What is the mechanism of the interaction?
Other clinical interaction. This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Ibuprofen — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
Browse all 174 medications in the A–Z directory.
DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 1,000 patients treated.
Last reviewed: May 2026 · See full medical team