Lisinopril
Zestril, Prinivil
Ibogaine and Glyburide
Also known as: Glibenclamide, Diabeta, Glynase, Micronase
Sulfonylureas force insulin secretion regardless of blood glucose, so they cause hypoglycaemia when a patient is not eating. Ibogaine treatment involves an extended fast and frequently vomiting, which is exactly the setting in which sulfonylurea hypoglycaemia becomes severe. Glyburide carries the highest hypoglycaemia risk of the class and has a long duration of action. Unlike metformin, holding is not optional.
Severity
Major risk
Mechanism
Other clinical interaction
Protocol Status
Continue as prescribed — cleared by a measured lab value, not a waiting period
Restart Delay
Physician discretion
What "Major risk" Means
Serious clinical risk requiring physician-led tapering, washout, and monitoring. Treatment may proceed once the medication is appropriately cleared or transitioned.
Clinical Action
What our medical team does for patients on Glyburide.
HOLD on the fasting and treatment day — this is not the 'monitor and maybe hold' handling that metformin gets. Check glucose at least q4h through the fast and the acute phase, and have oral or IV dextrose immediately available. Resume only when the patient is eating reliably.
Where the Washout Happens
Continue as prescribed — cleared by a measured lab value, not a waiting period
This medication is not stopped for treatment, and should not be stopped on our initiative — the condition it treats usually outranks the interaction. What it changes is monitoring: serum potassium and magnesium are measured before the flood dose and corrected to target, and the dose is deferred until those numbers are right rather than until a number of days have passed. Any change to the prescription belongs to the prescribing physician.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Glyburide interacts with ibogaine: other clinical interaction.
This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Same Mechanism
Other medications that interact via other clinical interaction.
Same Severity Tier
Other major risk medications (different mechanism).
Opioid receptor potentiation
Methadone
Methadose, Dolophine
Opioid receptor potentiation
Buprenorphine
Suboxone, Subutex
Opioid receptor potentiation
Fentanyl
Duragesic, Sublimaze
Opioid receptor potentiation
Oxycodone
Oxycontin, Percocet
Opioid receptor potentiation
Hydrocodone
Vicodin, Norco
Opioid receptor potentiation
Morphine
Ms Contin, Kadian
Common Questions
Glyburide and ibogaine treatment.
Can I take ibogaine if I am on Glyburide?
Major risk. Sulfonylureas force insulin secretion regardless of blood glucose, so they cause hypoglycaemia when a patient is not eating. Ibogaine treatment involves an extended fast and frequently vomiting, which is exactly the setting in which sulfonylurea hypoglycaemia becomes severe. Glyburide carries the highest hypoglycaemia risk of the class and has a long duration of action. Unlike metformin, holding is not optional. HOLD on the fasting and treatment day — this is not the 'monitor and maybe hold' handling that metformin gets. Check glucose at least q4h through the fast and the acute phase, and have oral or IV dextrose immediately available. Resume only when the patient is eating reliably.
How long do I need to be off Glyburide before ibogaine treatment?
Continue as prescribed — cleared by a measured lab value, not a waiting period. This medication is not stopped for treatment, and should not be stopped on our initiative — the condition it treats usually outranks the interaction. What it changes is monitoring: serum potassium and magnesium are measured before the flood dose and corrected to target, and the dose is deferred until those numbers are right rather than until a number of days have passed. Any change to the prescription belongs to the prescribing physician.
What is the mechanism of the interaction?
Other clinical interaction. This class has clinical considerations that do not fit a single mechanism category. Review the specific risk and clinical action for handling, and discuss with the prescribing physician.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Glyburide — contact us for an individual review.
Checking more than one medication? Use the interactive Drug Interaction Checker to screen your full medication list at once.
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DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 1,000 patients treated.
Last reviewed: May 2026 · See full medical team