Terbinafine
Lamisil
Ibogaine and Bupropion
Also known as: Wellbutrin, Zyban
Potent CYP2D6 inhibitor. Inhibits ibogaine metabolism, increasing blood levels and QTc prolongation risk. Also lowers seizure threshold.
Severity
Major risk
Mechanism
CYP2D6 inhibition
Protocol Status
Pre-arrival washout (under your prescribing physician)
Restart Delay
Physician discretion
What "Major risk" Means
Serious clinical risk requiring physician-led tapering, washout, and monitoring. Treatment may proceed once the medication is appropriately cleared or transitioned.
Clinical Action
What our medical team does for patients on Bupropion.
Discontinue minimum 7 days before treatment. Monitor for seizure risk.
Where the Washout Happens
Pre-arrival washout (under your prescribing physician)
Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose.
Pre-Treatment Washout Window
7 days minimum before treatment.
Post-Treatment Restart
Restart at physician discretion once acute window closes.
The Pharmacology
How Bupropion interacts with ibogaine: cyp2d6 inhibition.
Ibogaine is metabolised primarily by hepatic CYP2D6 into noribogaine. Drugs that inhibit CYP2D6 slow this conversion, so plasma ibogaine rises to higher peaks and stays there longer. Higher peaks deepen the experience and amplify QTc prolongation. CYP2D6-inhibiting medications are tapered and discontinued well before treatment to ensure predictable pharmacokinetics.
Same Mechanism
Other medications that interact via cyp2d6 inhibition.
Same Severity Tier
Other major risk medications (different mechanism).
Opioid receptor potentiation
Methadone
Methadose, Dolophine
Opioid receptor potentiation
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Suboxone, Subutex
Opioid receptor potentiation
Fentanyl
Duragesic, Sublimaze
Opioid receptor potentiation
Oxycodone
Oxycontin, Percocet
Opioid receptor potentiation
Hydrocodone
Vicodin, Norco
Opioid receptor potentiation
Morphine
Ms Contin, Kadian
Common Questions
Bupropion and ibogaine treatment.
Can I take ibogaine if I am on Bupropion?
Major risk. Potent CYP2D6 inhibitor. Inhibits ibogaine metabolism, increasing blood levels and QTc prolongation risk. Also lowers seizure threshold. Discontinue minimum 7 days before treatment. Monitor for seizure risk.
How long do I need to be off Bupropion before ibogaine treatment?
Pre-arrival washout (under your prescribing physician). Discontinuation is completed before arrival, under the patient's own prescribing physician, with the medication-specific washout interval observed before the flood dose. 7 days minimum before treatment.
What is the mechanism of the interaction?
CYP2D6 inhibition. Ibogaine is metabolised primarily by hepatic CYP2D6 into noribogaine. Drugs that inhibit CYP2D6 slow this conversion, so plasma ibogaine rises to higher peaks and stays there longer. Higher peaks deepen the experience and amplify QTc prolongation. CYP2D6-inhibiting medications are tapered and discontinued well before treatment to ensure predictable pharmacokinetics.
Can I switch to a different medication so I can have ibogaine treatment?
In many cases yes. Our medical team works with your prescribing physician to taper or substitute medications safely before treatment. The right substitution depends on the underlying condition you are treating with Bupropion — contact us for an individual review.
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DA
Medically reviewed by Dr. Arellano, M.D.
Clinical Director, MindScape Retreat · Board-certified physician specializing in ibogaine-assisted detoxification with over 900 patients treated.
Last reviewed: May 2026 · See full medical team