{
  "dataset": {
    "name": "Ibogaine Research Change Wire",
    "editorialReviewDate": "2026-11-05",
    "sourceRetrievedAt": "2026-11-06T04:50:41Z",
    "methodology": "Entries are manually reviewed field-level differences between two public ClinicalTrials.gov record versions. Registry update dates are not treated as study milestones or results publication dates.",
    "coverage": "Five monitored research records: three ClinicalTrials.gov studies and two official sponsor or program sources. Only registry-backed records can produce registry-diff entries."
  },
  "entries": [
    {
      "id": "nct04313712-v7-v8-enrollment-type",
      "studyId": "NCT04313712",
      "field": "/protocolSection/designModule/enrollmentInfo/type",
      "fieldLabel": "Enrollment classification",
      "changeKind": "modified",
      "before": "30 participants · estimated",
      "after": "30 participants · actual",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "The enrollment count remained 30, but its classification changed from estimated to actual. The number itself did not increase.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    },
    {
      "id": "nct04313712-v7-v8-investigator-title",
      "studyId": "NCT04313712",
      "field": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorTitle",
      "fieldLabel": "Responsible investigator title",
      "changeKind": "modified",
      "before": "Assistant Professor, Stanford University",
      "after": "Clinical Associate Professor, Stanford University",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "The responsible investigator's registered title changed to Clinical Associate Professor at Stanford University.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    },
    {
      "id": "nct04313712-v7-v8-overall-status",
      "studyId": "NCT04313712",
      "field": "/protocolSection/statusModule/overallStatus",
      "fieldLabel": "Overall recruitment status",
      "changeKind": "modified",
      "before": "Active, not recruiting",
      "after": "Completed",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "Stanford's registry status changed from active, not recruiting to completed. The study is not a current recruitment opportunity.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    },
    {
      "id": "nct04313712-v7-v8-primary-completion",
      "studyId": "NCT04313712",
      "field": "/protocolSection/statusModule/primaryCompletionDateStruct",
      "fieldLabel": "Primary completion date",
      "changeKind": "modified",
      "before": "February 2025 · estimated",
      "after": "13 September 2023 · actual",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "The registry replaced an estimated February 2025 primary completion date with the actual date, 13 September 2023.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    },
    {
      "id": "nct04313712-v7-v8-responsible-investigator",
      "studyId": "NCT04313712",
      "field": "/protocolSection/sponsorCollaboratorsModule/responsibleParty/investigatorFullName",
      "fieldLabel": "Responsible investigator",
      "changeKind": "modified",
      "before": "Nolan R",
      "after": "Cammie Ellen Rolle",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "The responsible-party record now names Cammie Ellen Rolle instead of Nolan R. Stanford University remained the lead sponsor.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    },
    {
      "id": "nct04313712-v7-v8-study-completion",
      "studyId": "NCT04313712",
      "field": "/protocolSection/statusModule/completionDateStruct",
      "fieldLabel": "Study completion date",
      "changeKind": "modified",
      "before": "February 2025 · estimated",
      "after": "13 September 2023 · actual",
      "registryUpdateSubmitted": "2026-10-22",
      "registryUpdatePosted": "2026-10-27",
      "editorialReviewDate": "2026-11-05",
      "summary": "The overall study completion date changed from an estimated future date to the actual date, 13 September 2023.",
      "limitation": "This registry edit is not a results posting and does not establish safety, efficacy, or comparative benefit.",
      "beforeEvidence": {
        "versionLabel": "Version 7 · submitted 17 December 2024",
        "submittedDate": "2024-12-17",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=7#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "d5978a82c56a3fcdea309ebc5ea29e148c39e9a5059d0e22ca14d1b20bd508f4"
      },
      "afterEvidence": {
        "versionLabel": "Version 8 · submitted 22 October 2026",
        "submittedDate": "2026-10-22",
        "sourceUrl": "https://clinicaltrials.gov/study/NCT04313712?tab=history&a=8#version-content-panel",
        "retrievedAt": "2026-11-06T04:50:41Z",
        "sha256": "44a696bf57a8a056191a7706c3f629169c2a6a6452ae6e5fcd22af77b8cad0d8"
      }
    }
  ]
}